Korostelev S A
Farmakol Toksikol. 1988 Jul-Aug;51(4):83-5.
The effects of leu-enkephalin and met-enkephalin on the number of the antibody-forming cells (AFC) in the mouse spleen at the primary immune response to ram erythrocytes depending on the dose and time of the agent administration with relation to the time of immunization were studied. The data indicating diverse effects of these endogenous opioid peptides on antibody genesis were obtained. When administered before immunization, met-enkephalin increased the number of AFC in the CBA mouse spleen and its administration simultaneously with an antigen and afterwards decreased the number of AFC. Leu-enkephalin both decreased and increased the number of AFC in the spleen in the dose-dependent way. The stimulating effect of this agent was more pronounced in the C57BL/6 mice with the initially low immune response as compared to the CBA mice.
研究了亮脑啡肽和甲硫脑啡肽对小鼠脾脏中抗体形成细胞（AFC）数量的影响，该影响是在对绵羊红细胞的初次免疫反应中，取决于药物给药的剂量和时间以及与免疫时间的关系。获得的数据表明这些内源性阿片肽对抗体产生具有不同的作用。在免疫前给药时，甲硫脑啡肽增加了CBA小鼠脾脏中AFC的数量，而在与抗原同时给药及之后给药时则减少了AFC的数量。亮脑啡肽以剂量依赖的方式既减少又增加了脾脏中AFC的数量。与CBA小鼠相比，这种药物的刺激作用在最初免疫反应较低的C57BL / 6小鼠中更为明显。
