Gao Shan, Song Siqi, Zhang Leiliang
Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
School of Basic Medicine, Qingdao University, Qingdao, China.
Front Microbiol. 2019 Dec 19;10:2881. doi: 10.3389/fmicb.2019.02881. eCollection 2019.
Chikungunya fever (CHIKF) is an acute infectious disease that is mediated by the mosquito-transmitted chikungunya virus (CHIKV). People infected with CHIKV may experience high fever, severe joint pain, skin rash, and headache. In recent years, this disease has become a global public health problem. However, there is no licensed vaccine available for CHIKV. Accumulating research data have provided novel approaches and new directions for the development of CHIKV vaccines. Our review focuses on recent progress in CHIKV vaccine studies. The potential vaccine candidates are classified into seven types: inactivated vaccine, subunit vaccine, live-attenuated vaccine, recombinant virus-vectored vaccine, virus-like particle vaccine, chimeric vaccine, and nucleic acid vaccine. These studies will provide important insights into the future development of CHIKV vaccines.
基孔肯雅热（CHIKF）是一种急性传染病，由蚊子传播的基孔肯雅病毒（CHIKV）介导。感染CHIKV的人可能会出现高烧、严重关节疼痛、皮疹和头痛。近年来，这种疾病已成为一个全球公共卫生问题。然而，目前尚无获批的CHIKV疫苗。越来越多的研究数据为CHIKV疫苗的开发提供了新方法和新方向。我们的综述重点关注CHIKV疫苗研究的最新进展。潜在的候选疫苗分为七种类型：灭活疫苗、亚单位疫苗、减毒活疫苗、重组病毒载体疫苗、病毒样颗粒疫苗、嵌合疫苗和核酸疫苗。这些研究将为CHIKV疫苗的未来发展提供重要见解。
