Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Immunol. 2019 Dec 18;10:2919. doi: 10.3389/fimmu.2019.02919. eCollection 2019.
Immunometabolism provides a new perspective on the pathogenesis of rheumatoid arthritis (RA). In recent years, there have been investigations focusing on the role of intracellular glucose metabolism in the pathogenesis of RA. Previous studies have shown that glycolysis of synovial tissue is increased in RA patients, while glycolysis inhibitors can significantly inhibit synovitis. Pyruvate kinase (PK) is a key enzyme in glycolysis, catalyzing the final rate-limiting step in the process. An isoform of PK, PKM2, provides favorable conditions for the survival of tumor cells via its glycolytic or non-glycolytic functions and has become a potential therapeutic target in tumors. RA synovium has the characteristic of tumor-like growth, and, moreover, increased expression of PKM2 was identified in the synovial tissue of RA patients in recent studies, indicating the underlying role of PKM2 in RA. PKM2 has potential value as a new therapeutic target or biomarker for RA, but its exact role in RA remains unclear. In this review, the properties of PKM2 and existing research concerning PKM2 and RA are thoroughly reviewed and summarized, and the possible role and mechanism of PKM2 in RA are discussed.
免疫代谢为类风湿关节炎 (RA) 的发病机制提供了新的视角。近年来，人们越来越关注细胞内葡萄糖代谢在 RA 发病机制中的作用。先前的研究表明，RA 患者的滑膜组织糖酵解增加，而糖酵解抑制剂可显著抑制滑膜炎。丙酮酸激酶 (PK) 是糖酵解的关键酶，催化该过程的最后限速步骤。PK 的同工酶 PKM2 通过其糖酵解或非糖酵解功能为肿瘤细胞的存活提供有利条件，已成为肿瘤的潜在治疗靶点。RA 滑膜具有肿瘤样生长的特征，此外，最近的研究还发现 RA 患者滑膜组织中 PKM2 的表达增加，表明 PKM2 在 RA 中的潜在作用。PKM2 作为 RA 的新治疗靶点或生物标志物具有潜在价值，但它在 RA 中的确切作用尚不清楚。本文对 PKM2 的特性以及 PKM2 与 RA 的现有研究进行了全面回顾和总结，并探讨了 PKM2 在 RA 中的可能作用和机制。
