Daneshfard Babak, Shahriari Mahdi, Heiran Alireza, Nimrouzi Majid, Yarmohammadi Hassan
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Essence of Parsiyan Wisdom Institute, Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran.
Avicenna J Phytomed. 2020 Jan-Feb;10(1):58-69.
Chemotherapy-induced neutropenia is one of the main side effects of acute lymphoblastic leukemia (ALL) treatment. In this trial, we evaluated the efficacy of chamomile in management of neutropenia.
This randomized triple-blind placebo-controlled clinical trial was carried out in 2-18-year-old children with ALL. Participants in each group daily received 2.5 ml of either chamomile syrup or placebo syrup for a period of 30 days. Participants' white blood cell (WBC), and absolute neutrophil count (ANC), as well as their quality of life were evaluated.
The study was completed with a total of 40 patients. An increasing trend of ANC was observed in the treatment group despite the decreasing trend in placebo group, which was statistically significant between the two groups (P Interaction=0.019, 95% confidence intervals=15.076-171.324). No serious side effects were reported.
Using chamomile syrup as a complementary therapy in children with leukemia could improve their immunity (as it increased WBC) by minimizing chemotherapy-induced neutropenia.
化疗引起的中性粒细胞减少是急性淋巴细胞白血病（ALL）治疗的主要副作用之一。在本试验中，我们评估了洋甘菊在治疗中性粒细胞减少方面的疗效。
本随机三盲安慰剂对照临床试验在2至18岁的ALL儿童中进行。每组参与者每天服用2.5毫升洋甘菊糖浆或安慰剂糖浆，持续30天。评估参与者的白细胞（WBC）、绝对中性粒细胞计数（ANC）以及他们的生活质量。
该研究共纳入40名患者。治疗组的ANC呈上升趋势，而安慰剂组呈下降趋势，两组之间差异具有统计学意义（P交互作用=0.019，95%置信区间=15.076 - 171.324）。未报告严重副作用。
在白血病患儿中使用洋甘菊糖浆作为辅助治疗，可通过减少化疗引起的中性粒细胞减少来提高其免疫力（因为它增加了WBC）。
