L'Huillier Arnaud G, Brito Francisco, Wagner Noemie, Cordey Samuel, Zdobnov Evgeny, Posfay-Barbe Klara M, Kaiser Laurent
Division of Pediatric Infectious Diseases, Department of Pediatrics, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Front Pediatr. 2019 Dec 19;7:524. doi: 10.3389/fped.2019.00524. eCollection 2019.
Kawasaki disease is an acute pediatric vasculitis whose etiology remains unknown but epidemiology and clinical presentation suggest a viral etiology. We performed unbiased high-throughput-sequencing on blood of patients with Kawasaki Disease (KD). High-throughput-sequencing was performed directly on blood of children with typical KD. Sequences were aligned against a database of clinically relevant viruses. Four patients were acutely infected in the blood, with respectively, poliovirus (vaccine strain), measles (vaccine strain), rhinovirus and bocavirus. Patients with poliovirus and measles had received oral polio and measles vaccines, respectively, twelve and 2 weeks prior. Viral signatures were identified in more than half of the patients, including some corresponding to their vaccinal history. This could suggest a temporal association with KD.
川崎病是一种急性儿童血管炎，其病因尚不清楚，但流行病学和临床表现提示为病毒病因。我们对川崎病（KD）患者的血液进行了无偏倚的高通量测序。直接对典型KD患儿的血液进行高通量测序。将序列与临床相关病毒数据库进行比对。4例患者血液中有急性感染，分别为脊髓灰质炎病毒（疫苗株）、麻疹病毒（疫苗株）、鼻病毒和博卡病毒。脊髓灰质炎病毒和麻疹患者分别在12周和2周前接种过口服脊髓灰质炎疫苗和麻疹疫苗。在超过半数的患者中发现了病毒特征，包括一些与其疫苗接种史相符的特征。这可能提示与KD存在时间关联。
