Steiner Richard, Dhar Madhu, Stephenson Stacy M, Newby Steven, Bow Austin, Pedersen Alisha, Anderson David E
Veterinary Medical Center, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United States.
Department of Surgery, University of Tennessee Medical Center, Knoxville, Knoxville, TN, United States.
Front Vet Sci. 2019 Dec 20;6:469. doi: 10.3389/fvets.2019.00469. eCollection 2019.
Pressure mapping systems are often used for indirect assessment of kinematic gait parameter differences after repair of critical peripheral nerve defects in small animal models. However, there does not appear to be any literature that studies the differences in normal gait pattern of Sprague Dawley rats compared to Lewis rats using a Tekscan VH4 pressure mat system. The purpose of this study is to assess the gait profile of Lewis and Sprague Dawley rats generated by Tekscan's VH4 system to detect similarities and/or differences in gait parameters involving both force and temporal variables. The gait profile of 14 Lewis and 14 Sprague Dawley rats was recorded using a Tekscan VH4 pressure map system with two successful walks per animal and gait parameter data was normalized for mean variance between the two rodent strains. The results showed that temporal and normalized force parameters were not significantly different between the two types of rats. Maximum force, contact area, stride length, and adjusted pressure variables were significantly different between the two strains, likely attributed to the body size and weight differential between the strains. Variation in some of these parameters were considered due to differences in overall body size between the two strains, variations in gait kinematics between individual rodent subjects, and the limitations of the current experimental design. : For future models, either Sprague Dawley or Lewis rat strains would be acceptable animal models when comparing base-line gait profiles using the Tekscan VH4 pressure map system when assessing critical defect repairs of peripheral nerves.
压力映射系统常用于间接评估小动物模型中关键周围神经缺损修复后运动步态参数的差异。然而，似乎没有任何文献使用Tekscan VH4压力垫系统研究与Lewis大鼠相比，Sprague Dawley大鼠正常步态模式的差异。本研究的目的是评估Tekscan的VH4系统生成的Lewis和Sprague Dawley大鼠的步态概况，以检测涉及力和时间变量的步态参数的相似性和/或差异。使用Tekscan VH4压力图系统记录了14只Lewis大鼠和14只Sprague Dawley大鼠的步态概况，每只动物成功行走两次，并对步态参数数据进行归一化处理，以计算两种啮齿动物品系之间的平均方差。结果表明，两种类型的大鼠在时间和归一化力参数上没有显著差异。两种品系之间的最大力、接触面积、步长和调整后的压力变量存在显著差异，这可能归因于品系之间的体型和体重差异。考虑到这些参数中的一些差异是由于两种品系之间总体体型的差异、个体啮齿动物受试者之间步态运动学的差异以及当前实验设计的局限性。对于未来的模型，在使用Tekscan VH4压力图系统比较基线步态概况以评估周围神经的关键缺损修复时，Sprague Dawley或Lewis大鼠品系都是可接受的动物模型。
