Lawrence W D, Qureshi F, Bonakdar M I
Department of Pathology, Hutzel Hospital, Detroit, MI 48201.
Hum Pathol. 1988 Dec;19(12):1467-70. doi: 10.1016/s0046-8177(88)80243-0.
A case of the chronic type of placental polyp, occurring in a 37-year-old woman approximately 9 years after abortion of her last known pregnancy, is reported. The placental polyp was predominantly composed of necrotic and hyalinized chorionic villi without identifiable lining trophoblast; however, some villi showed a thin rim of apparently viable syncytiotrophoblast that exhibited focal strong positivity for human chorionic gonadotropin by immunohistochemical studies. Intermediate trophoblast, especially abundant within the intervillous fibrin, appeared most viable and showed strong positivity for human placental lactogen (hPL); syncytiotrophoblast also showed focal positivity for hPL. The basal aspect of the polyp was composed of abundant decidua that contained dilated and ectatic blood vessels. This study demonstrates the presence of cytoplasmic markers for pregnancy in a chronic type of placental polyp, apparently of 9 years' duration, and draws attention to an entity that may be encountered more frequently due to the current prevalence of induced abortions.
本文报道了一例慢性胎盘息肉病例，患者为37岁女性，在其最后一次已知妊娠流产约9年后发病。胎盘息肉主要由坏死和玻璃样变的绒毛膜绒毛组成，无明确的滋养层衬里；然而，一些绒毛显示出一层薄的、明显存活的合体滋养层，免疫组化研究显示其对人绒毛膜促性腺激素呈局灶性强阳性。中间型滋养层在绒毛间隙纤维蛋白中特别丰富，似乎最具活力，对人胎盘催乳素（hPL）呈强阳性；合体滋养层对hPL也呈局灶性阳性。息肉的底部由丰富的蜕膜组成，其中含有扩张和迂曲的血管。本研究证明，在一例病程显然长达9年的慢性胎盘息肉中存在妊娠的细胞质标志物，并提醒人们注意，由于目前人工流产的普遍存在，这种病变可能会更频繁地遇到。
