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语义变异型原发性进行性失语症和阿尔茨海默病患者言语情景记忆表现的差异认知基础。

Differential cognitive substrates of verbal episodic memory performance in semantic variant primary progressive aphasia and Alzheimer's disease.

机构信息

Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.

Palo Alto University, California, USA.

出版信息

J Neuropsychol. 2021 Apr;15 Suppl 1(Suppl 1):1-7. doi: 10.1111/jnp.12200. Epub 2020 Jan 10.

DOI:10.1111/jnp.12200
PMID:31922650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7347458/
Abstract

Performance on neuropsychological measures of verbal memory requires cognitive abilities beyond memory. We examined the contribution of semantic knowledge in verbal episodic memory for semantic variant primary progressive aphasia (svPPA) or Alzheimer's disease (AD). 415 AD and 68 svPPA participants completed measures of episodic memory (visual and verbal) and semantic knowledge. A double dissociation existed visual recall predicted verbal recognition in AD, whereas semantic knowledge contributed to verbal recognition in svPPA.

摘要

在神经心理学的言语记忆测试中,表现需要超越记忆的认知能力。我们研究了语义知识对语义变异型原发性进行性失语症(svPPA)或阿尔茨海默病(AD)的言语情景记忆的贡献。415 名 AD 患者和 68 名 svPPA 患者完成了情景记忆(视觉和言语)和语义知识的测试。AD 患者中存在视觉回忆预测言语识别的双重分离,而 svPPA 患者的语义知识对言语识别有贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bc/7347458/ac510fdcacaf/nihms-1582821-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bc/7347458/ac510fdcacaf/nihms-1582821-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5bc/7347458/ac510fdcacaf/nihms-1582821-f0001.jpg

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本文引用的文献

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Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications.语义记忆在阿尔茨海默病病程早期是否持续受损?神经解剖学及诊断意义。
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