Colle M L, Asch R H, Greenblatt R B
J Reprod Med. 1977 Jan;18(1):31-4.
The relative roles of the central nervous system and pituitary in the pathogenesis of olfactory gonadal dysplasia has been the subject of much speculation. Repeated stimulation of the pituitary gonadal axis with LH-RH provoked a moderate release of gonadotropins, insufficient however, to stimulate gonadal incretory function. This study supports the evidence that a hypothalamic defect is the basis for Kallman's syndrome.
中枢神经系统和垂体在嗅觉性腺发育不全发病机制中的相对作用一直是诸多猜测的主题。用促黄体生成素释放激素（LH-RH）反复刺激垂体性腺轴可引起促性腺激素适度释放，但不足以刺激性腺分泌功能。本研究支持如下证据，即下丘脑缺陷是卡尔曼综合征的基础。
