Orthopaedic Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
Key Laboratory of Automobile Materials of MOE, Department of Materials Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110430. doi: 10.1016/j.msec.2019.110430. Epub 2019 Nov 21.
Functionalization of porous metals with antibacterial coatings is hotly pursued in recent decade. Here we fabricated a highly porous stainless steel component by selective laser melting and then coated with silver incorporated zeolite by in situ hydrothermal crystallization method. The morphology of their surface was investigated by scanning electron microscopy. The inhibition of Escherichia coli and Staphylococcus aureus were identified by bacterial viability studies after 24 h of incubation. More importantly, the obtained coatings show better osteointegration by spreading bone marrow stromal cells (BMSCs) after cultured with different scaffold extract solutions for 1, 3, and 5 days. These results suggest that silver incorporated zeolite coatings on 3D printed porous stainless steels exhibit better antibacterial activity and biocompatibility, showing potential application in the field of medical implant materials.
近年来,多孔金属的抗菌涂层功能化受到了广泛关注。在这里,我们通过选择性激光熔化制造了一种高度多孔的不锈钢部件,然后通过原位水热结晶法涂覆了掺入银的沸石。通过扫描电子显微镜研究了它们表面的形态。通过孵育 24 小时后进行细菌活力研究来鉴定大肠杆菌和金黄色葡萄球菌的抑制作用。更重要的是,在不同支架浸提液中培养 1、3 和 5 天后,获得的涂层在骨髓基质细胞 (BMSCs) 上表现出更好的骨整合性。这些结果表明,3D 打印多孔不锈钢上的掺入银的沸石涂层具有更好的抗菌活性和生物相容性,在医用植入材料领域具有潜在的应用前景。