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功能化沸石调节骨代谢微环境。

Functionalized zeolite regulates bone metabolic microenvironment.

作者信息

Xu Mingwei, Liu He, Zhang Jiaxin, Xu Meng, Zhao Xin, Wang Jincheng

机构信息

Orthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun, 130041, China.

出版信息

Mater Today Bio. 2025 Feb 5;31:101558. doi: 10.1016/j.mtbio.2025.101558. eCollection 2025 Apr.

DOI:10.1016/j.mtbio.2025.101558
PMID:40034985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11874869/
Abstract

The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, bone defects, infections, and tumors remains a significant challenge in orthopedics. Therefore, it has become urgent to develop biomaterials with effective bone metabolic microenvironmental regulatory functions. Zeolites, as advanced biomedical materials, possess distinctive physicochemical properties such as multi-level pore structures, adjustable frameworks, easily modifiable surfaces, and excellent adsorption capabilities. These advantageous characteristics give zeolites broad application prospects in regulating the bone metabolic microenvironment. Therefore, this paper first classifies zeolites used to regulate the bone metabolic microenvironment based on their topological structures and compositional frameworks. Subsequently, it provides a detailed description of modification strategies for zeolite materials aimed at regulating this microenvironment. Next, a comprehensive summary was provided on the preparation strategies for zeolite materials aimed at regulating the bone metabolic microenvironment. Additionally, the paper focuses on the specific applications of zeolite materials in conditions of bone metabolic imbalance, such as osteoporosis, bone defects, orthopedic infections, and bone tumors, highlighting their potential in enhancing osteogenic microenvironments, controlling infections, and treating bone tumors. Finally, it outlines the prospects and challenges associated with the application of zeolites in regulating the bone metabolic microenvironment. This review comprehensively summarizes zeolites used for bone metabolic regulation, aiming to provide guidance for future research and application development.

摘要

在骨质疏松症、骨缺损、感染和肿瘤等疾病中，骨代谢微环境失衡的调控仍是骨科领域的一项重大挑战。因此，开发具有有效骨代谢微环境调控功能的生物材料变得迫在眉睫。沸石作为先进的生物医学材料，具有独特的物理化学性质，如多级孔结构、可调节的骨架、易于修饰的表面和优异的吸附能力。这些优势特性赋予了沸石在调控骨代谢微环境方面广阔的应用前景。因此，本文首先根据拓扑结构和组成骨架对用于调控骨代谢微环境的沸石进行分类。随后，详细描述了旨在调控该微环境的沸石材料的改性策略。接下来，对旨在调控骨代谢微环境的沸石材料的制备策略进行了全面总结。此外，本文重点关注了沸石材料在骨代谢失衡状况下的具体应用，如骨质疏松症、骨缺损、骨科感染和骨肿瘤，突出了它们在增强成骨微环境、控制感染和治疗骨肿瘤方面的潜力。最后，概述了沸石在调控骨代谢微环境应用中面临的前景和挑战。本综述全面总结了用于骨代谢调控的沸石，旨在为未来的研究和应用开发提供指导。

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