Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
Centre for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110487. doi: 10.1016/j.msec.2019.110487. Epub 2019 Nov 27.
It remains challenging to build up a multifunctional coating onto biodegradable magnesium (Mg) for biomedical use. In this study, a small amount of titanium dioxide (TiO) has been incorporated in situ into phytic acid (PA) coating when it was chemically deposited on Mg substrate targeted to biodegradable implant applications. Ultraviolet (UV) irradiation was utilized in the liquid phase deposition of TiO to improve the quality of coating (PA&TiO-UV). This PA&TiO-UV coating was compact, thicker and more hydrophilic compared with sole PA or TiO coating. The PA&TiO-UV coated Mg presented a seven times lower electrochemical corrosion current density as well as significantly slower in vitro degradation rate up to 500 h in phosphate buffer saline as compared to the direct PA coated Mg. In addition, the UV irradiation showed remarkably to promote the MC3T3-E1 pre-osteoblast cells adhesion and proliferation especially after 7 days of culture. Further, the PA&TiO-UV coating adhered more firmly on Mg substrate after 90° bending than the other coatings, indicating a better mechanical compliance on Mg substrate. These results make this PA&TiO-UV complex coating bodes well for biodegradation slowing-down, osteo-compatible as well as mechanical compliant modification of Mg for orthopedic implants applications.
将多功能涂层构建到可生物降解的镁（Mg）上仍然具有挑战性，用于生物医学用途。在这项研究中，当将其化学沉积在 Mg 基底上以用于可生物降解的植入物应用时，在植酸（PA）涂层中就地掺入了少量的二氧化钛（TiO）。紫外线（UV）照射用于 TiO 的液相沉积，以改善涂层（PA&TiO-UV）的质量。与单独的 PA 或 TiO 涂层相比，这种 PA&TiO-UV 涂层更致密、更厚、更亲水。与直接涂覆 PA 的 Mg 相比，涂覆有 PA&TiO-UV 的 Mg 的电化学腐蚀电流密度低七倍，在磷酸盐缓冲盐水（PBS）中的体外降解率也明显较慢，可达 500 h。此外，UV 照射显著促进 MC3T3-E1 前成骨细胞的粘附和增殖，尤其是在培养 7 天后。此外，PA&TiO-UV 涂层在 90°弯曲后比其他涂层更牢固地附着在 Mg 基底上，表明其在 Mg 基底上具有更好的机械顺应性。这些结果表明，这种 PA&TiO-UV 复合涂层有望用于减缓镁的生物降解、骨相容性以及机械顺应性改性，以用于骨科植入物应用。
