School of Community and Global Health, Claremont Graduate University, The Claremont Colleges, Claremont, CA, USA.
Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, NY, USA.
Ann Behav Med. 2020 Jun 12;54(7):510-517. doi: 10.1093/abm/kaz069.
Obesity is a cardiovascular disease risk factor and affects approximately 13.7 million U.S. children and adolescents between the ages 2 and 19 years old in 2015-2016.
To determine the relationship between children's average long-term exposure to maternal depressive symptoms age 1 month to Grade 6 and adolescents' body mass index (BMI) z-score at age 15 mediated by the adolescents' depressive symptom experience.
A total of 1,364 infants and their families from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Study of Early Child Care and Youth Development were recruited.
Mediation analyses revealed a significant relationship between children's average long-term exposure to maternal depressive symptoms from age 1 month to Grade 6 and adolescents' BMI z-score at age 15 (total effect = 0.015, p = .013, 95% confidence interval (CI): 0.0032, 0.027). The adolescents' experience of depressive symptoms significantly mediated this relationship (indirect effect = 0.0021, bias-corrected bootstrapped 95% CI: 0.0004, 0.0044), with this mediated relationship more pronounced in girls.
Findings indicate the possible existence of a mediating role of adolescents' depressive symptoms experience in the pathway from average long-term exposure to maternal depressive symptoms during children's early life to adolescents' elevated BMI.
肥胖是心血管疾病的一个风险因素，影响了 2015-2016 年美国约 1370 万名 2 至 19 岁的儿童和青少年。
确定儿童从 1 个月大到 6 年级期间平均长期暴露于母亲抑郁症状与 15 岁青少年的体重指数（BMI）z 分数之间的关系，其中通过青少年的抑郁症状体验进行中介。
共有 1364 名婴儿及其家庭参加了儿童健康与人类发展国家研究所的幼儿早期保育和青年发展研究。
中介分析显示，儿童从 1 个月大到 6 年级期间平均长期暴露于母亲抑郁症状与 15 岁青少年 BMI z 分数之间存在显著关系（总效应=0.015，p=0.013，95%置信区间（CI）：0.0032，0.027）。青少年的抑郁症状体验显著中介了这种关系（间接效应=0.0021，偏倚校正的自举 95%CI：0.0004，0.0044），这种中介关系在女孩中更为明显。
研究结果表明，青少年抑郁症状体验可能在儿童早期母亲抑郁症状的平均长期暴露与青少年 BMI 升高之间的途径中发挥中介作用。
