Liu Chang, Song Yiyue, Wang Xiaoran, Lai Zhaoguang, Li Chaoyang, Wan Pengxia, Xu Nuo, Huang Danping, Liu Yizhi, Wang Zhichong
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China,
Ophthalmic Res. 2020;63(3):320-331. doi: 10.1159/000503636. Epub 2020 Jan 10.
To examine whether dry eye severity is a risk factor for pterygium activity and whether vascular endothelial growth factor (VEGF) is crucial in the cross talk between pterygium and dry eye.
A total of 103 patients with primary pterygium (Pteg) were included in the study group; they were divided into 2 groups according to the complication of dry eye (DE) (Pteg + DE group, Pteg - DE group). Further, 60 patients with just dry eye (DE group) and 60 normal individuals (normal) were included as 2 control groups. DE severity and pterygium activity were measured, and unstimulated tear samples and pterygium tissues were collected for cytokine detection.
(1) Tear detection: VEGF expression increased in the Pteg + DE group compared to the Pteg - DE, DE, and normal control groups; VEGF was especially increased in the active Pteg + DE group. VEGF concentration was positively correlated with pterygium activity. (2) Tissue detection: the mRNA expression of VEGF was upregulated in the active pterygium group.
Inflammation played an important role in the development of dry eye and pterygium. VEGF was the core molecule in the cross talk, which might explain the high incidence of the coexistence of these 2 diseases.
探讨干眼严重程度是否为翼状胬肉活动的危险因素，以及血管内皮生长因子（VEGF）在翼状胬肉与干眼的相互作用中是否起关键作用。
研究组共纳入103例原发性翼状胬肉患者；根据干眼并发症（DE）将其分为2组（翼状胬肉+干眼组、翼状胬肉-干眼组）。此外，纳入60例单纯干眼患者（干眼组）和60例正常个体（正常组）作为2个对照组。测量干眼严重程度和翼状胬肉活动度，并收集未刺激的泪液样本和翼状胬肉组织进行细胞因子检测。
（1）泪液检测：与翼状胬肉-干眼组、干眼组和正常对照组相比，翼状胬肉+干眼组的VEGF表达增加；在活跃的翼状胬肉+干眼组中VEGF尤其增加。VEGF浓度与翼状胬肉活动度呈正相关。（2）组织检测：活跃翼状胬肉组中VEGF的mRNA表达上调。
炎症在干眼和翼状胬肉的发生发展中起重要作用。VEGF是相互作用中的核心分子，这可能解释了这两种疾病共存的高发生率。
