Defore W W, Mattox K L, Dang M H, Crawford R, Jordan G L
JACEP. 1977 Feb;6(2):62-5. doi: 10.1016/s0361-1124(77)80036-1.
Necrotizing fasciitis is a rare but specific clinical entity which, if not diagnosed early and treated aggressively, is rapidly fatal. The disease was first described during the Civil War and continues to be associated with a 50% mortality. The infectious process is diagnosed by the presence of a widespread fascial necrosis with extensive undermining of the adjacent tissues. The initial mechanism of injury as well as the location and etiologic agent of the suppurative fasciitis may vary. A review of 41 cases of necrotizing fasciitis occurring over a 22-year period disclosed an overall mortality of 39%. Most often, the mortality was related to the severity of the associated diseases and a failure to recognize the disease process promptly. The rate may be lowered by early recognition and prompt surgical intervention coupled with intensive supportive therapy.
坏死性筋膜炎是一种罕见但特殊的临床病症，若不及早诊断并积极治疗，会迅速致命。该病最早在内战期间被描述，至今死亡率仍达50%。感染过程可通过广泛的筋膜坏死伴相邻组织广泛潜行性破坏来诊断。化脓性筋膜炎的初始损伤机制、部位及病原体可能各不相同。一项对22年间发生的41例坏死性筋膜炎病例的回顾显示，总死亡率为39%。多数情况下，死亡率与相关疾病的严重程度以及未能及时识别疾病进程有关。早期识别、及时手术干预并辅以强化支持治疗可降低死亡率。
