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从榕属植物地上部分提取的新化合物及其抗氧化和抗炎活性。

New compounds from the aerial parts of Burm.f. and their antioxidant and anti-inflammatory activities.

机构信息

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China.

出版信息

Nat Prod Res. 2021 Oct;35(20):3478-3486. doi: 10.1080/14786419.2019.1710708. Epub 2020 Jan 13.

Abstract

Three new compounds (-), together with six known compounds (-), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Burm.f. All of these known compounds were isolated from the plant for the first time. Their structures including absolute configurations were elucidated on the basis of HR-ESI-MS, NMR spectroscopic analyses, single crystal X-ray diffraction and comparison with the literatures. Compounds - were tested for their antioxidant and anti-inflammatory activities. Compounds and showed the antioxidant activities with IC values of 28.61 ± 1.56 and 22.55 ± 1.38 M, respectively. Compounds and showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC values of 20.95 ± 1.11 and 16.50 ± 1.04 M, respectively.

摘要

从 Burm.f. 的地上部分的乙醇提取物的乙酸乙酯部分分离得到三种新化合物 (-),以及六种已知化合物 (-)。所有这些已知化合物均为首次从该植物中分离得到。基于高分辨电喷雾电离质谱(HR-ESI-MS)、NMR 光谱分析、单晶 X 射线衍射和与文献的比较,确定了它们的结构,包括绝对构型。测试了化合物 (-) 的抗氧化和抗炎活性。化合物 - 表现出抗氧化活性,IC 值分别为 28.61 ± 1.56 和 22.55 ± 1.38 M。化合物 - 在 LPS 诱导的 RAW 264.7 巨噬细胞中表现出抗炎活性,IC 值分别为 20.95 ± 1.11 和 16.50 ± 1.04 M。

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