Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston. MA, USA.
Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.
J Biol Regul Homeost Agents. 2019 Nov-Dec;33(6):1663-1667. doi: 10.23812/19-33n6Edit_Theoharides.
Neurodevelopment has been studied extensively, especially in respect to abuse, anoxia, nutritional status and prematurity/low birth weight. However, less attention has been paid to innate and environmental factors, as well as to inflammatory conditions that may adversely affect neurodevelopment and learning in children. These include heavy metals, herbicides and polyvinyl chlorides (PVCs), mycotoxins, viral infections and Lyme disease-associated pathogens, as well as number of conditions such as chronic inflammatory response syndrome (CIRS) and Mast cell activation syndrome (MCAS). Early recognition of factors/conditions that could interfere with neurodevelopment is critical. Corrective actions, including the use of some unique natural flavonoids, could have lasting beneficial results.
神经发育已经得到了广泛的研究，特别是在滥用、缺氧、营养状况和早产/低出生体重方面。然而，人们对先天和环境因素以及可能对儿童神经发育和学习产生不利影响的炎症状态关注较少。这些因素包括重金属、除草剂和聚氯乙烯 (PVC)、霉菌毒素、病毒感染和莱姆病相关病原体，以及一些疾病，如慢性炎症反应综合征 (CIRS) 和肥大细胞激活综合征 (MCAS)。早期识别可能干扰神经发育的因素/状况至关重要。纠正措施，包括使用一些独特的天然类黄酮，可能会产生持久的有益效果。
