Vaishnavi C, Ganguly N K, Kumar B, Kaur S
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian J Lepr. 1988 Apr;60(2):242-51.
Nonspecific macrophage functions were studied in Mycobacterium leprae infected and preformed immune complex (IC) administered normal (NI) and thymectomized/irradiated (TRI) mice at different time periods. Uninfected controls given IC were also included. Significant decrease in the chemotaxis, phagocytosis and bactericidal activities of macrophages obtained from infected groups compared to their controls were observed. Phagocytic and chemotactic activities of macrophages were normal but intracellular killing was seen to be depressed in studies conducted in normal and thymectomized immunosuppressed groups (Vaishnavi et al., 1985, Kumar et al, 1987) which were not administered with preformed IC.
在不同时间段，对感染麻风分枝杆菌并注射了预先形成的免疫复合物（IC）的正常（NI）小鼠和胸腺切除/照射（TRI）小鼠的非特异性巨噬细胞功能进行了研究。还纳入了给予IC的未感染对照。与对照组相比，观察到感染组巨噬细胞的趋化性、吞噬作用和杀菌活性显著降低。在未注射预先形成的IC的正常和胸腺切除免疫抑制组（Vaishnavi等人，1985年；Kumar等人，1987年）进行的研究中，巨噬细胞的吞噬和趋化活性正常，但细胞内杀伤作用受到抑制。
