Stress Physiology Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Neurosci Biobehav Rev. 2020 Apr;111:12-18. doi: 10.1016/j.neubiorev.2020.01.011. Epub 2020 Jan 10.
Stressful experiences can be transmitted among individuals through social interactions. Like humans, rodents are social creatures whose behavior and physiology can be influenced by the emotional state of fellow rodents. This paper will review rodent studies which have explored two conditions of potential social stress contagion using the social defeat paradigm. In the vicarious social defeat model, mice and rats that witness a conspecific being socially defeated exhibit physiological stress responses and develop a host of depressive- and anxiety-like behavioral deficits. Likewise, social interaction with a stressed partner in the aftermath of social defeat stress results in physiological stress responses and social avoidance behavior. After summarizing the existing literature on this newly emerging area of social defeat stress contagion in rodents, we will discuss the potential utility of these rodent models for investigating the neurobiological processes and sensory channels of information that allow for the spread of psychophysiological effects of stress across individuals.
应激体验可以通过社交互动在个体间传递。与人类一样，啮齿动物也是社会性动物，它们的行为和生理机能可以受到同伴情绪状态的影响。本文将回顾使用社交挫败范式探索两种潜在社交应激传染情况的啮齿动物研究。在替代性社交挫败模型中，目睹同种动物被社交挫败的老鼠会表现出应激的生理反应，并出现一系列类似抑郁和焦虑的行为缺陷。同样，在社交挫败应激后与受应激的同伴进行社交互动会导致生理应激反应和社交回避行为。在总结了关于啮齿动物社交挫败应激传染这一新兴领域的现有文献后，我们将讨论这些啮齿动物模型在研究允许应激的心理生理效应在个体间传播的神经生物学过程和感觉通道方面的潜在应用。
