Nilsson U, Oste R, Jägerstad M, Birkhed D
Department of Applied Nutrition, University of Lund, Sweden.
J Nutr. 1988 Nov;118(11):1325-30. doi: 10.1093/jn/118.11.1325.
The bioavailability of cereal fructans (fructooligosaccharides) was investigated both in vitro and in vivo. In vitro studies indicated very slow hydrolysis by human gastric juice and by homogenate of the intestinal mucosa (rat). After intubation of fructans into the stomachs of rats, the recovery of fructans in the small intestine and colon was approximately the same as that of an unabsorbed marker (polyethylene glycol), indicating no or very low disappearance of fructans in the small intestine. In vivo studies of the small intestine in rats showed that the rate of disappearance of fructans was lower than that of mannose, which is known to be absorbed through passive diffusion. In addition the cariogenic effect of cereal fructans was compared to that of glucose. Acid formation from low molecular-weight fructans was found in human dental plaque in vitro. A mouth rinse with unfractionated fructans, containing some quantities of sucrose, fructose and glucose, resulted in relatively low pH values in human plaque in vivo, even if the decrease in pH was somewhat less pronounced when compared with a mouth rinse with glucose.
对谷物果聚糖（低聚果糖）的生物利用度进行了体外和体内研究。体外研究表明，人胃液和肠黏膜匀浆（大鼠）对其水解非常缓慢。将果聚糖插管注入大鼠胃内后，小肠和结肠中果聚糖的回收率与未吸收标记物（聚乙二醇）的回收率大致相同，表明果聚糖在小肠中无消失或消失极少。对大鼠小肠进行的体内研究表明，果聚糖的消失速率低于甘露糖，已知甘露糖通过被动扩散被吸收。此外，还将谷物果聚糖的致龋作用与葡萄糖的致龋作用进行了比较。在体外人牙菌斑中发现了低分子量果聚糖产酸的情况。用含有一定量蔗糖、果糖和葡萄糖的未分级果聚糖进行口腔冲洗，在体内人牙菌斑中会导致相对较低的pH值，即便与用葡萄糖进行口腔冲洗相比，pH值的降低不太明显。
