• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

致命性脑梗死和眼动脉阻塞后鼻用透明质酸填充术:病例报告及文献复习。

Fatal Cerebral Infarction and Ophthalmic Artery Occlusion After Nasal Augmentation with Hyaluronic Acid-A Case Report and Review of Literature.

机构信息

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, Shaanxi, China.

Department of Plastic and Reconstructive Surgery, Changan Hospital, Xi'an, 710016, Shaanxi, China.

出版信息

Aesthetic Plast Surg. 2020 Apr;44(2):543-548. doi: 10.1007/s00266-019-01589-x. Epub 2020 Jan 13.

DOI:10.1007/s00266-019-01589-x
PMID:31932889
Abstract

BACKGROUND

Cerebral infarction is a rare complication of hyaluronic acid (HA) filler injection, usually presenting with sudden increase in intracranial pressure and loss of vision.

METHODS

A 40-year-old Asian woman in a coma was transferred to the emergency intensive care unit of Xijing Hospital, China, 48 h after nasal augmentation with HA. Magnetic resonance imaging indicated cerebral infarction and left optic nerve edema and ischemia. Magnetic resonance angiography did not reveal vessel embolism.

RESULTS

The patient developed gastric ulceration, pulmonary infection, respiratory failure, and cerebral herniation, and died 6 days after the HA filler injection.

CONCLUSION

Facial cosmetic HA filler injection can cause devastating and even fatal complications.

LEVEL OF EVIDENCE V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

摘要

背景

脑梗死是透明质酸(HA)填充剂注射的罕见并发症,通常表现为颅内压突然升高和视力丧失。

方法

一名 40 岁的亚洲女性在接受 HA 鼻整形术后 48 小时陷入昏迷,被转入中国西京医院急诊重症监护病房。磁共振成像显示脑梗死和左侧视神经水肿和缺血。磁共振血管造影未显示血管栓塞。

结果

患者发生胃溃疡、肺部感染、呼吸衰竭和脑疝,在 HA 填充剂注射后 6 天死亡。

结论

面部美容 HA 填充剂注射可导致严重甚至致命的并发症。

证据等级 V:本杂志要求作者为每篇文章指定一个证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者指南 www.springer.com/00266。

相似文献

1
Fatal Cerebral Infarction and Ophthalmic Artery Occlusion After Nasal Augmentation with Hyaluronic Acid-A Case Report and Review of Literature.致命性脑梗死和眼动脉阻塞后鼻用透明质酸填充术:病例报告及文献复习。
Aesthetic Plast Surg. 2020 Apr;44(2):543-548. doi: 10.1007/s00266-019-01589-x. Epub 2020 Jan 13.
2
Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature.与透明质酸填充物相关的视力丧失:文献系统评价。
Aesthetic Plast Surg. 2020 Jun;44(3):929-944. doi: 10.1007/s00266-019-01562-8. Epub 2019 Dec 10.
3
Reversal of Post-filler Vision Loss and Skin Ischaemia with High-Dose Pulsed Hyaluronidase Injections.高剂量脉冲透明质酸酶注射逆转填充后视力丧失和皮肤缺血。
Aesthetic Plast Surg. 2019 Oct;43(5):1337-1344. doi: 10.1007/s00266-019-01421-6. Epub 2019 Jun 24.
4
Clinical Observations and the Anatomical Basis of Blindness After Facial Hyaluronic Acid Injection.面部透明质酸注射后失明的临床观察及解剖学基础
Aesthetic Plast Surg. 2019 Aug;43(4):1054-1060. doi: 10.1007/s00266-019-01374-w. Epub 2019 Apr 21.
5
Death from Pulmonary Embolism Caused by Vaginal Injection of Hyaluronic Acid: a Case Report and a Literature Review.阴道注射透明质酸致肺栓塞死亡:1例报告及文献复习
Aesthetic Plast Surg. 2023 Aug;47(4):1535-1541. doi: 10.1007/s00266-023-03265-7. Epub 2023 Feb 6.
6
Temporary blindness after an anterior chamber cosmetic filler injection.前房注射美容填充剂后出现的暂时性失明。
Aesthetic Plast Surg. 2015 Jun;39(3):428-30. doi: 10.1007/s00266-015-0477-9. Epub 2015 Apr 1.
7
Administration Method and Potential Efficacy of Hyaluronidase for Hyaluronic Acid Filler-Related Vision Loss: A Systematic Review.透明质酸酶治疗透明质酸填充剂相关视力丧失的给药方法和潜在疗效:系统评价。
Aesthetic Plast Surg. 2024 Feb;48(4):709-718. doi: 10.1007/s00266-022-03215-9. Epub 2022 Dec 27.
8
Significant Vision Recovery from Filler-Induced Complete Blindness with Combined Intra-Arterial Injection of Hyaluronidase and Thrombolytic Agents.联合应用透明质酸酶和溶栓药物经动脉内注射治疗导致的完全失明后视力的显著恢复。
Aesthetic Plast Surg. 2022 Apr;46(2):907-911. doi: 10.1007/s00266-021-02658-w. Epub 2021 Nov 12.
9
Cerebral Angiographic Findings of Cosmetic Facial Filler-related Ophthalmic and Retinal Artery Occlusion.美容面部填充剂相关的眼动脉和视网膜动脉阻塞的脑血管造影表现
J Korean Med Sci. 2015 Dec;30(12):1847-55. doi: 10.3346/jkms.2015.30.12.1847. Epub 2015 Nov 30.
10
Adverse Events Associated with Hyaluronic Acid Filler Injection for Non-surgical Facial Aesthetics: A Systematic Review of High Level of Evidence Studies.与非手术面部美容用透明质酸填充剂注射相关的不良事件:高证据水平研究的系统评价。
Aesthetic Plast Surg. 2024 Feb;48(4):719-741. doi: 10.1007/s00266-023-03465-1. Epub 2023 Aug 10.

引用本文的文献

1
Cerebral Venous Thrombosis Following Periocular Filler Injection-A Case Report and Review of Literature.眼周填充剂注射后发生的脑静脉血栓形成——病例报告及文献综述
Case Rep Neurol Med. 2025 Sep 3;2025:9363655. doi: 10.1155/crnm/9363655. eCollection 2025.
2
Anatomical Mapping of Nasal Arteries in Chilean Patients Using Doppler Ultrasound: Clinical Application for Injectables.使用多普勒超声对智利患者鼻动脉进行解剖学定位:注射剂的临床应用
Aesthet Surg J Open Forum. 2025 Mar 11;7:ojaf016. doi: 10.1093/asjof/ojaf016. eCollection 2025.
3
Effect of Xiao's double C nursing model on motor function, daily living activities, and quality of life in stroke patients.
肖氏双C护理模式对脑卒中患者运动功能、日常生活活动能力及生活质量的影响
Medicine (Baltimore). 2025 Feb 14;104(7):e41456. doi: 10.1097/MD.0000000000041456.
4
The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers within an Artificial Model of Arterial Embolism.凝胶参数对透明质酸凝胶填充剂在动脉栓塞人工模型中的扩散和破碎的影响
Gels. 2024 Aug 12;10(8):530. doi: 10.3390/gels10080530.
5
"Filler-Associated Acute Stroke Syndrome": Classification, Predictive Modelling of Hyaluronidase Efficacy, and Updated Case Review on Neurological and Visual Complications.“填充剂相关急性卒中综合征”:分类、透明质酸酶疗效的预测模型,以及神经和视觉并发症的最新病例复习。
Aesthetic Plast Surg. 2024 Sep;48(17):3222-3253. doi: 10.1007/s00266-024-04202-y. Epub 2024 Jul 7.
6
Nonsurgical Rhinoplasty: An Updated Systematic Review of Technique, Outcomes, Complications, and Its Treatments.非手术隆鼻术:技术、效果、并发症及其治疗的最新系统评价
Aesthetic Plast Surg. 2024 Dec;48(23):4902-4915. doi: 10.1007/s00266-024-04161-4. Epub 2024 Jun 11.
7
Disastrous cerebral and ocular vascular complications after cosmetic facial filler injections: a retrospective case series study.美容面部填充物注射后灾难性的脑和眼部血管并发症:一项回顾性病例系列研究。
Sci Rep. 2024 Feb 12;14(1):3495. doi: 10.1038/s41598-024-54202-w.
8
Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions.不同面部区域填充剂注射所致栓塞的临床表现及预后
Plast Reconstr Surg Glob Open. 2023 Aug 29;11(8):e5225. doi: 10.1097/GOX.0000000000005225. eCollection 2023 Aug.
9
Multi-modal fMRI and TMS follow-up study of motor cortical stroke caused by hyaluronic acid filler: A case report.透明质酸填充剂致运动性皮质卒中的多模态功能磁共振成像与经颅磁刺激随访研究:一例报告
Front Neurol. 2022 Sep 8;13:903648. doi: 10.3389/fneur.2022.903648. eCollection 2022.
10
Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)-Implications for Therapeutic Interventions.百年难题的破解:透明质酸填充剂诱导血管闭塞(FIVO)的病理生理学和分子机制——对治疗干预的启示。
Molecules. 2022 Aug 24;27(17):5398. doi: 10.3390/molecules27175398.