Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
Sarcoma Center, West German Cancer Center, University of Duisburg-Essen, Essen, Germany.
J Cancer Res Clin Oncol. 2020 Apr;146(4):953-960. doi: 10.1007/s00432-019-03121-9. Epub 2020 Jan 13.
Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.
SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.
The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).
The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.
The causes for these variations require further exploration.
在滑膜肉瘤（SS）患者中，年龄较大与预后较差相关。然而，目前尚不清楚不同年龄组之间疾病表现的差异。
评估了 1981 年至 2018 年期间连续 CWS 试验中登记的年龄<21 岁的 SS 患者。使用 Fisher 精确检验根据年龄组分析特征。
研究人群包括 432 名 SS 患者。根据年龄组，儿童（0-12 岁，n=176）、青少年（13-16 岁，n=178）和年轻成人（17-21 岁，n=78）的疾病特征不同。侵袭性肿瘤（T2）的比例在年龄较大的患者中显著更高：儿童为 33%，青少年为 39%，年轻成人为 54%，p=0.009805。同样，肿瘤>10cm 的比例更高（13%、21%、31%；p=0.005657），而相反，较小肿瘤<3cm 的比例在年龄较大的患者中较低（29%、24%、6%；p=0.000104）。初次诊断时存在转移的比例在年龄较大的患者中也最高（6%、10%、21%，p=0.000963）。值得注意的是，大腿肿瘤的比例在年龄较大的患者中较高（p=0.04173），而头颈部肿瘤的比例在年龄较大的患者中较低（p=0.08896）。
大、侵袭性肿瘤的比例和转移的存在与患者年龄较大显著相关。大腿部位的肿瘤在年龄较大的患者中更为常见。
这些变化的原因需要进一步探讨。
