Machado Thatiane C G, Guatimosim Cristina, Kangussu Lucas M
Departamento de Morfologia - Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Protein Pept Lett. 2020;27(6):456-462. doi: 10.2174/0929866527666200110154523.
Huntington's Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder characterized by severe symptoms, including motor impairment, cognitive decline, and psychiatric alterations. Several systems, molecules, and mediators have been associated with the pathophysiology of HD. Among these, there is the Renin-Angiotensin System (RAS), a peptide hormone system that has been associated with the pathology of neuropsychiatric and neurodegenerative disorders. Important alterations in this system have been demonstrated in HD. However, the role of RAS components in HD is still unclear and needs further investigation. Nonetheless, modulation of the RAS components may represent a potential therapeutic strategy for the treatment of HD.
亨廷顿舞蹈症（HD）是一种常染色体显性进行性神经退行性疾病，其特征为出现严重症状，包括运动障碍、认知衰退和精神状态改变。多个系统、分子和介质都与HD的病理生理学相关。其中，肾素 - 血管紧张素系统（RAS）是一种肽激素系统，已被证明与神经精神疾病和神经退行性疾病的病理相关。HD患者体内该系统出现了重要改变。然而，RAS各组分在HD中的作用仍不明确，需要进一步研究。尽管如此，调节RAS各组分可能是治疗HD的一种潜在策略。
