Bauerlein Deanna K, Akbar Hashem N, von Rosenvinge Erik C, Loughry Nora D, John Preeti R
Veterans Affairs New Jersey Healthcare System, USA.
Tufts University Medical Center, USA.
Case Reports Hepatol. 2019 Dec 17;2019:4730381. doi: 10.1155/2019/4730381. eCollection 2019.
-Acetylcysteine (NAC) is reported to have multiple clinical applications in addition to being the specific antidote for acetaminophen toxicity. NAC stimulates glutathione biosynthesis, promotes detoxification, and acts directly as a scavenger of free radicals. It is a powerful antioxidant and a potential treatment option for diseases characterized by the generation of free oxygen radicals. We present a case of postoperative hepatic dysfunction of multifactorial etiology in a patient with therapeutic acetaminophen levels, where hepatic function improved considerably following administration of intravenous NAC. This case suggests that NAC should be considered for treatment of acute liver dysfunction in the postoperative setting, even in the absence of elevated acetaminophen levels.
乙酰半胱氨酸（NAC）除了是对乙酰氨基酚中毒的特效解毒剂外，还具有多种临床应用。NAC刺激谷胱甘肽的生物合成，促进解毒，并直接作为自由基清除剂发挥作用。它是一种强大的抗氧化剂，也是治疗以氧自由基产生为特征的疾病的潜在治疗选择。我们报告了一例术后肝功能不全的病例，病因多因素，患者对乙酰氨基酚水平处于治疗范围，静脉注射NAC后肝功能显著改善。该病例表明，即使对乙酰氨基酚水平未升高，术后急性肝功能不全的治疗也应考虑使用NAC。
