World J Gastroenterol. 2010 Apr 21;16(15):1937-8. doi: 10.3748/wjg.v16.i15.1937.
We have read with interest the paper published in issue 2, volume 16 of World Journal of Gastroenterology 2010 by Nakamura et al, demonstrating that the antioxidant resveratrol (RVT) enhances hepatitis C virus (HCV) replication, consequently, they conclude that RVT is not a suitable antioxidant therapy for HCV chronic infection. The data raise some concern regarding the use of complementary and alternative medicine since the most frequent supplements taken by these patients are antioxidants or agents that may be beneficial for different chronic liver diseases. A recent study by Vidali et al on oxidative stress and steatosis in the progression of chronic hepatitis C concludes that oxidative stress and insulin resistance contribute to steatosis, thus accelerating the progression of fibrosis. We are particularly interested in investigating how the oxidative and nitrosative stress mechanisms are involved in the pathogenesis of different chronic liver diseases.
我们饶有兴趣地阅读了 Nakamura 等人在 2010 年第 16 卷第 2 期《世界胃肠病学杂志》上发表的论文，该论文表明抗氧化剂白藜芦醇（RVT）可增强丙型肝炎病毒（HCV）的复制，因此他们得出结论，RVT 不适合用于 HCV 慢性感染的抗氧化治疗。由于这些患者最常服用的补充剂是抗氧化剂或可能对不同慢性肝病有益的药物，因此这些数据引发了对补充和替代医学使用的一些担忧。Vidali 等人最近关于慢性丙型肝炎进展中的氧化应激和脂肪变性的研究得出结论，氧化应激和胰岛素抵抗导致脂肪变性，从而加速纤维化的进展。我们特别感兴趣的是研究氧化和硝化应激机制如何参与不同慢性肝病的发病机制。
