肝转移胰腺癌新辅助FOLFIRINOX治疗后胰腺癌的病理完全缓解
Pathologic Complete Response of Pancreatic Cancer following Neoadjuvant FOLFIRINOX Treatment in Hepatic Metastasized Pancreatic Cancer.
作者信息
Luu Andreas Minh, Hoehn Philipp, Vogel Sina Rabea, Reinacher-Schick Anke, Munding Johanna, Uhl Waldemar, Braumann Chris
机构信息
Department of General and Visceral Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Department of Oncology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
出版信息
Visc Med. 2019 Dec;35(6):387-391. doi: 10.1159/000497827. Epub 2019 Apr 3.
INTRODUCTION
Pancreatic cancer is a lethal disease and often asymptomatic. Therefore, it is most often diagnosed at an advanced stage. The standard approach in a metastasized tumor stage is palliative chemotherapy. However, the prognosis remains extremely poor.
CASE REPORT
We present the case of a patient who was diagnosed with a cancer of the head of the pancreas with hepatic metastases. After receiving palliative intended chemotherapy with the FOLFIRINOX regimen, staging computed tomography revealed the disappearance of the liver metastases and local resectability of the pancreatic head tumor. The patient underwent an uneventful Whipple's procedure. Surprisingly, pathohistological investigation revealed a complete pathological response.
CONCLUSION
Pathological complete response after FOLFIRINOX treatment in hepatic metastasized pancreatic cancer is extremely rare. It enables surgical resection and increases the survival rate significantly.
引言
胰腺癌是一种致命疾病，通常没有症状。因此，它最常被诊断为晚期。转移性肿瘤阶段的标准治疗方法是姑息化疗。然而，预后仍然极差。
病例报告
我们报告一例被诊断为胰头癌伴肝转移的患者。在接受了以FOLFIRINOX方案进行的姑息性化疗后，分期计算机断层扫描显示肝转移灶消失，胰头肿瘤可进行局部切除。患者顺利接受了Whipple手术。令人惊讶的是，病理组织学检查显示完全病理缓解。
结论
FOLFIRINOX治疗肝转移胰腺癌后出现病理完全缓解极为罕见。它能实现手术切除并显著提高生存率。
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