Mizumoto K, Tsutsumi M, Denda A, Konishi Y
Department of Oncological Pathology, Nara Medical College, Japan.
J Natl Cancer Inst. 1988 Dec 7;80(19):1564-7. doi: 10.1093/jnci/80.19.1564.
A rapid-production model incorporating the principle of selection by resistance to cytotoxicity demonstrated earlier for liver carcinogenesis in rats was established for pancreatic carcinoma development in Syrian hamsters. Adenocarcinomas were induced in 84% of treated animals by 10 weeks after initiation with 70 mg of N-nitroso-bis(2-oxopropyl)amine (BOP) per kg of body weight when augmentation pressure (choline-deficient diet combined with DL-ethionine and L-methionine and administration of 20 mg/kg BOP upon return to basal diet) was applied three times. A 52% yield of cholangiocellular tumors also resulted from this experimental protocol.
利用先前在大鼠肝癌发生中证明的对细胞毒性抗性选择原则，建立了一种快速生成模型，用于叙利亚仓鼠胰腺癌的发展。当每千克体重给予70毫克N-亚硝基双（2-氧代丙基）胺（BOP）起始后10周，通过三次施加增强压力（胆碱缺乏饮食与DL-乙硫氨酸和L-甲硫氨酸联合，并在恢复基础饮食时给予20毫克/千克BOP），84%的受试动物诱发了腺癌。该实验方案还产生了52%的胆管细胞肿瘤发生率。
