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Lower LDL is better - can this be achieved with CETP inhibition therapy?

作者信息

Rashid Shirya

机构信息

Department of Public Health, North South University, Dhaka, Bangladesh.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Expert Rev Cardiovasc Ther. 2020 Jan;18(1):1-5. doi: 10.1080/14779072.2020.1715797. Epub 2020 Jan 23.

DOI:10.1080/14779072.2020.1715797
PMID:31937166
Abstract
摘要

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Lower LDL is better - can this be achieved with CETP inhibition therapy?降低低密度脂蛋白更好——通过抑制胆固醇酯转运蛋白（CETP）疗法能否实现这一目标？
Expert Rev Cardiovasc Ther. 2020 Jan;18(1):1-5. doi: 10.1080/14779072.2020.1715797. Epub 2020 Jan 23.
2
On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study).他汀类药物治疗后胆固醇酯转移蛋白质量与复发性冠状动脉事件风险（来自普伐他汀或阿托伐他汀评估与感染治疗-心肌梗死溶栓 22 试验[PROVE IT-TIMI 22 研究]）。
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Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E177-90. doi: 10.1152/ajpendo.00528.2014. Epub 2015 May 26.
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CETP inhibition, statins and diabetes.CETP 抑制剂、他汀类药物与糖尿病。
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引用本文的文献

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Missing in action: the genetic mysteries of extremely low HDL cholesterol.行动缺失：极低高密度脂蛋白胆固醇的遗传奥秘
Front Cardiovasc Med. 2025 May 22;12:1553259. doi: 10.3389/fcvm.2025.1553259. eCollection 2025.
2
Structure-based mechanism and inhibition of cholesteryl ester transfer protein.基于结构的胆固醇酯转移蛋白的作用机制及抑制作用
Curr Atheroscler Rep. 2023 Apr;25(4):155-166. doi: 10.1007/s11883-023-01087-1. Epub 2023 Mar 7.
3
Cholesteryl Ester Transfer Protein Inhibition Reduces Major Adverse Cardiovascular Events by Lowering Apolipoprotein B Levels.
胆固醇酯转移蛋白抑制剂通过降低载脂蛋白 B 水平降低主要不良心血管事件。
Int J Mol Sci. 2022 Aug 20;23(16):9417. doi: 10.3390/ijms23169417.
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Cholesteryl ester transfer protein inhibitors: from high-density lipoprotein cholesterol to low-density lipoprotein cholesterol lowering agents?胆固醇酯转移蛋白抑制剂：从高密度脂蛋白胆固醇到低密度脂蛋白胆固醇降低剂？
Cardiovasc Res. 2022 Nov 10;118(14):2919-2931. doi: 10.1093/cvr/cvab350.
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HDL in Atherosclerotic Cardiovascular Disease: In Search of a Role.载脂蛋白高密度脂蛋白在动脉粥样硬化性心血管疾病中的作用：探寻新的可能。
Cells. 2021 Jul 23;10(8):1869. doi: 10.3390/cells10081869.