Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland; Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Eur Urol Focus. 2021 Jan;7(1):186-189. doi: 10.1016/j.euf.2019.12.004. Epub 2020 Jan 11.
Lower urinary tract dysfunction affects a multitude of patients. Current therapeutic approaches are limited and very little is known about the mechanisms in failure of bladder control. Thus, more basic research is clearly needed to elucidate the underlying pathological mechanisms and to develop novel treatment strategies in urology. Noninvasive tests such as the void-spot assay and the metabolic cage and more invasive urodynamics investigations are currently used to assess lower urinary tract function in animals, in particular rodents. The noninvasive tests give some insights into the functionality of the system, whereas urodynamics testing yields an objective evaluation that allows distinction of different pathologies and investigations of the underlying neuronal malfunctions. PATIENT SUMMARY: We briefly summarize methods currently used to assess impairments of bladder function in animal models. Both noninvasive and invasive methods are available and can be used to understand and improve human health. An accurate and detailed diagnosis is, however, possible only with urodynamics assessments.
下尿路功能障碍影响众多患者。目前的治疗方法有限，对膀胱控制失败的机制知之甚少。因此，显然需要更多的基础研究来阐明潜在的病理机制，并在泌尿科开发新的治疗策略。目前，非侵入性测试（如排空点测定和代谢笼）和更具侵入性的尿动力学研究用于评估动物，特别是啮齿动物的下尿路功能。非侵入性测试提供了对系统功能的一些了解，而尿动力学测试则提供了客观的评估，可以区分不同的病理，并研究潜在的神经功能障碍。
我们简要总结了目前用于评估动物模型中膀胱功能障碍的方法。有非侵入性和侵入性方法可供选择，可用于了解和改善人类健康。然而，只有通过尿动力学评估才能进行准确和详细的诊断。
