Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Khartoum, Sudan; Neurology Unit, Gafer Ibn Auf Specialized hospital for Children, Sudan.
Department of Psychiatry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Epilepsy Behav. 2020 Feb;103(Pt A):106813. doi: 10.1016/j.yebeh.2019.106813. Epub 2020 Jan 11.
Many studies of selected groups of children with epilepsy have demonstrated an association between epilepsy and cognitive deficits. The aim of this study was to assess the intellectual skills of children with epilepsy and to investigate the influence of gender, age at seizure onset, type of epilepsy, antiepileptic drug used, and control of epilepsy on their intellectual function.
This is a descriptive prospective study in which one hundred and eighty-seven patients at school age (6-14 years) were recruited. Epilepsy was classified using the International League Against Epilepsy (ILAE) Commission on Classification and Terminology 2005-2009 report. An intelligence quotient (IQ) test was conducted to all patients using Stanford-Binet Fifth Edition (SB5)/Arabic version.
Eighty-eight (47.1%) patients had an average score on Full Scale IQ (FSIQ), 44 (23.5%) had low average, whereas 18 (9.6%) had borderline impaired or delayed score. In the nonverbal IQ (NVIQ) score, the majority 84 (44.9%) had average score. The performance of the patients in the nonverbal score is better than in the verbal score, which was found to be statistically significant (P-value = 0.01). The FSIQ score was negatively affected by younger age at onset of epilepsy, polytherapy, and uncontrolled seizures.
Most of children with epilepsy had an average FSIQ; uncontrolled seizure had worse effect on overall FSIQ and memory. Interventions to support children with epilepsy should focus on epilepsy management and school psychosocial domains.
许多针对特定癫痫患儿群体的研究表明，癫痫与认知缺陷之间存在关联。本研究旨在评估癫痫患儿的智力技能，并探讨性别、发病年龄、癫痫类型、抗癫痫药物的使用以及癫痫控制对其智力功能的影响。
这是一项描述性前瞻性研究，共招募了 187 名学龄期（6-14 岁）患儿。癫痫使用国际抗癫痫联盟（ILAE）2005-2009 年分类和术语委员会报告进行分类。使用斯坦福-比奈第五版（SB5）/阿拉伯语版对所有患者进行智商（IQ）测试。
88 名（47.1%）患者的全量表智商（FSIQ）平均得分，44 名（23.5%）得分较低，18 名（9.6%）得分处于边缘受损或延迟状态。在非言语智商（NVIQ）评分中，84 名（44.9%）患者的得分处于平均水平。患者在非言语得分方面的表现优于言语得分，这具有统计学意义（P 值=0.01）。FSIQ 评分受癫痫发病年龄较小、多药治疗和未控制的癫痫发作的负面影响。
大多数癫痫患儿的 FSIQ 处于平均水平；未控制的癫痫发作对整体 FSIQ 和记忆力的影响更差。支持癫痫患儿的干预措施应侧重于癫痫管理和学校社会心理领域。
