Yan Weifeng, Wang Xiaolin, Pei Yuxin, Chen Fan, Wang Jianru
Department of Orthopaedics, The Hospital of Zhejiang General Corps of Armed Police Forces Jiaxing, China.
Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The 6th Affiliated Hospital of Sun Yat-sen University Guangzhou, China.
Int J Clin Exp Pathol. 2018 Apr 1;11(4):2017-2024. eCollection 2018.
Intervertebral disc degeneration (IVDD) is the main cause of low back pain and has become a worldwide problem causing enormous economic loss. Thus, mechanisms and treatment of IVDD are attracting great attention from surgeons and physicians. The syndecan (SDC) family has been reported to play important roles in various physiopathologic processes. In this study, we found that SDC2 expression levels were positively correlated with IVDD grades in human samples. Moreover, we demonstrated that transforming growth factor-β1 inhibited SDC2 expression through ERK1/2 signaling pathway activation in nucleus pulposus cells. Knocking down SDC2 in disc cells significantly suppressed aggrecanase-1 and aggrecanase-2 expression. The results of our study indicate that SDC2 may be a therapeutic target through which extracellular matrix degradation of IVDD can be controlled.
椎间盘退变（IVDD）是腰痛的主要原因，已成为一个导致巨大经济损失的全球性问题。因此，IVDD的发病机制及治疗方法正引起外科医生和内科医生的高度关注。据报道，多功能蛋白聚糖（SDC）家族在多种生理病理过程中发挥重要作用。在本研究中，我们发现人样本中SDC2的表达水平与IVDD分级呈正相关。此外，我们证明转化生长因子-β1通过激活髓核细胞中的ERK1/2信号通路来抑制SDC2表达。敲低椎间盘细胞中的SDC2可显著抑制聚集蛋白聚糖酶-1和聚集蛋白聚糖酶-2的表达。我们的研究结果表明，SDC2可能是一个治疗靶点，通过该靶点可以控制IVDD的细胞外基质降解。
