Division of Nuclear Medicine and Molecular Imaging, 75 Francis St, Brigham and Women's Hospital, Boston, MA 02115.
AJR Am J Roentgenol. 2020 Mar;214(3):641-648. doi: 10.2214/AJR.19.21894. Epub 2020 Jan 15.
Fluciclovine is a synthetic radiolabeled amino acid analog used for imaging of biochemical recurrent prostate cancer. Uptake of fluciclovine is mediated by several amino acid transporters, including alanine-serine-cysteine transporter 2 and large neutral amino acid transporters, which are known to be overexpressed in other malignancies. Knowledge of the common patterns of prostate cancer recurrence, in addition to what other neoplasms can show uptake, is critical for accurate study interpretation.
氟尿苷是一种用于生化复发性前列腺癌成像的合成放射性标记氨基酸类似物。氟尿苷的摄取由多种氨基酸转运蛋白介导，包括丙氨酸-丝氨酸-半胱氨酸转运蛋白 2 和大中性氨基酸转运蛋白，这些蛋白在其他恶性肿瘤中已知过度表达。了解前列腺癌复发的常见模式，以及哪些其他肿瘤可以摄取氟尿苷，对于准确解读研究结果至关重要。
