铜催化的烯基取代氮杂芳烃的不对称硅基加成反应。
Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes.
作者信息
Zeng Ya-Li, Chen Bo, Wang Ya-Ting, He Cheng-Yu, Mu Zi-Yuan, Du Ji-Yuan, He Long, Chu Wen-Dao, Liu Quan-Zhong
机构信息
Chemical Synthesis and Pollution Control, Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, No. 1, Shida Road, Nanchong 637002, China.
出版信息
Chem Commun (Camb). 2020 Feb 6;56(11):1693-1696. doi: 10.1039/c9cc08910a.
Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee).
在与易于获得的手性亚磷酰胺配体配位的铜催化剂存在下，二甲基苯基硅硼酸频哪醇酯与多种氮杂芳基烯烃进行不对称共轭加成反应，以高收率（高达96%）和优异的对映选择性（高达97% ee）得到有用的β-硅基氮杂芳烃。
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