Keramat Fariba, Alikhani Mohammad Yousef, Poorolajal Jalal, Akbari Surur
Hamadan University of Medical Sciences, Hamadan, Iran.
J Infect Dev Ctries. 2018 Jun 30;12(6):448-453. doi: 10.3855/jidc.9731.
The human immune system including phagocytosis, has anessential role in pathogenesis, relapse and improvement of infectious diseases. The immune cells have vitamin D receptor, and vitamin D deficiency causes impaired immune system, specifically macrophages. The aim of study was to compare serum levelof 25-hydroxyvitamin D3 (25-OH- VitD3) among the patients with acute brucellosis and relapsed brucellosis with healthy individuals.
In this case-control study, 92 patients with acute brucellosis, 92 cases with relapsed brucellosis and 107 healthy persons who referred to Sina hospital and Imam Khomeini clinic were enrolled, and all groups were matched based on age, gender and habitat. The study was done from March 2016 to June 2017. The serum levels of 25-OH- VitD3 were measured based on the Enzyme Linked Fluorescent Assay (ELFA) technology, Vidassystem (France, Biomerieux Kit). The data were analyzed by using SPSS version 16 software.
The mean serum levels of 25-OH- VitD3 in acute brucellosis, relapsed brucellosis and healthy persons were 22.55 ± 15.72, 26.82 ± 20.78, 24.44 ± 17.29, respectively .In addition, the mean serum levels of 25-OH- VitD3 by male gender in acute brucellosis, relapsed brucellosis and healthy control groups were 20.35 ± 13.10, 24.88 ± 20.89 and 22.52 ± 13.79, respectively. However, there was no statistically significant difference among three groups (P = 0.275).
According to the results, the prevalence of vitamin D deficiency was high in patients with acute or relapsed brucellosis and also healthy persons; however, there was no meaningful difference among three groups and between the patients and healthy persons.
包括吞噬作用在内的人体免疫系统在传染病的发病机制、复发和改善过程中起着至关重要的作用。免疫细胞具有维生素D受体，维生素D缺乏会导致免疫系统受损，尤其是巨噬细胞。本研究的目的是比较急性布鲁氏菌病患者、复发性布鲁氏菌病患者和健康个体的血清25-羟基维生素D3（25-OH-VitD3）水平。
在这项病例对照研究中，纳入了92例急性布鲁氏菌病患者、92例复发性布鲁氏菌病患者以及107名前往新浪医院和伊玛目霍梅尼诊所就诊的健康人，所有组均根据年龄、性别和居住地进行匹配。研究于2016年3月至2017年6月进行。基于酶联荧光分析（ELFA）技术、维达斯系统（法国，生物梅里埃试剂盒）测量血清25-OH-VitD3水平。使用SPSS 16版软件对数据进行分析。
急性布鲁氏菌病患者、复发性布鲁氏菌病患者和健康人的血清25-OH-VitD3平均水平分别为22.55±15.7２、26.82±20.78、24.44±17.29。此外，急性布鲁氏菌病组、复发性布鲁氏菌病组和健康对照组男性的血清25-OH-VitD3平均水平分别为20.35±13.10、24.88±20.89和22.52±13.79。然而，三组之间无统计学显著差异（P = 0.275）。
根据研究结果，急性或复发性布鲁氏菌病患者以及健康人中维生素D缺乏的患病率都很高；然而，三组之间以及患者与健康人之间没有显著差异。
