Surace Alessandra, Liberale Viola, D'Alonzo Marta, Pecchio Silvia, Baù Maria Grazia, Biglia Nicoletta
Department of Obstetrics and Gynecology, AOU City of Health and Science, University of Turin, Turin, Italy.
Department of Obstetrics and Gynecology, Umberto I Hospital, University of Turin, Turin, Italy.
Am J Case Rep. 2020 Jan 16;21:e919856. doi: 10.12659/AJCR.919856.
BACKGROUND Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign breast lesion. CASE REPORT PASH is reported in a young female in treatment for neurological diseases with multi-drug therapy (clonazepam, valproate and risperidone). Her menstrual cycles are irregular, and she reached menarche very late. CONCLUSIONS The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in 24% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate, risperidone and progesterone could increase the level of progesterone that could stimulate PASH growth.
背景 假血管瘤样间质增生（PASH）是一种罕见的乳腺良性病变。病例报告 一名年轻女性因神经疾病接受多药治疗（氯硝西泮、丙戊酸盐和利培酮）时被诊断为PASH。她月经周期不规律，初潮很晚。结论 绝经前女性（其中大多数正在积极服用口服避孕药）、24%至47%的男性乳腺增生患者以及孕期PASH的患病率较高，这支持了激素病因学；氯硝西泮、丙戊酸盐、利培酮与孕酮之间的相互作用可能会增加孕酮水平，从而刺激PASH生长。
