根皮提取物对Wistar白化大鼠细菌和化学诱导腹泻的治疗作用()。 （注：括号部分原文缺失内容，翻译时保留原样）
Therapeutic effects of root bark extract on bacterially and chemically induced diarrhea in the Wistar albino rat ().
作者信息
Sunday Ejeh Augustine, Onyeyili Patrick Azubuike, Saganuwan Saganuwan Alhaji
机构信息
Department of Veterinary Physiology and Biochemistry Faculty of Veterinary Medicine University of Abuja FCT Nigeria.
Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine Federal University of Agriculture Makurdi Benue State Nigeria.
出版信息
Animal Model Exp Med. 2019 Dec 18;2(4):312-325. doi: 10.1002/ame2.12094. eCollection 2019 Dec.
BACKGROUND
Diarrhea can be caused by pathogenic microorganisms and chemicals. In view of this, Schum and Thonn (Connaraceae) was used to treat diarrhea induced by castor oil or bacteria in Wistar albino rats.
METHODS
Qualitative and quantitative analyses of an aqueous root back extract of were made and the acute toxicity, antidiarrhea properties, and in vitro and in vivo antimicrobial activities of the extract were investigated in rats.
RESULTS
The phytochemical analysis of the root bark extract revealed the presence of flavonoids, alkaloid, saponins, tannins, and phenols. The quantitative analysis showed that saponins formed 10.6% of the extract, tannins 7.6%, flavonoids 6.2%, phenol 5.8% and alkaloids 4.4%. A dose limit of 5000 mg/kg was safe to use in the rats. At a dose of 100 mg/kg, the extract decreased distance travelled by activated charcoal in the gastrointestinal tract, frequency of defecation, and number of unformed faeces caused by castor oil-induced diarrhea, and led to 74.96% inhibition of the diarrhea effects. and were susceptible to higher concentrations of the extract with a minimum inhibitory concentration of 0.3125 mg/mL. -infected rats showed depression, weight loss, anorexia, diarrhea, and weakness, which was ameliorated by the extract on day 2 post treatment. Observed congestion, cellular infiltration and necrosis of the liver, intestine and kidney following infection were improved by the extract.
CONCLUSION
extract can be used in the treatment of anaemia, and castor oil- and -induced diarrhea in rats.
背景
腹泻可由致病微生物和化学物质引起。鉴于此，在Wistar白化大鼠中使用了Schum和Thonn（使君子科）来治疗蓖麻油或细菌引起的腹泻。
方法
对其根皮水提取物进行定性和定量分析，并在大鼠中研究该提取物的急性毒性、抗腹泻特性以及体外和体内抗菌活性。
结果
根皮提取物的植物化学分析显示存在黄酮类化合物、生物碱、皂苷、单宁和酚类。定量分析表明，皂苷占提取物的10.6%，单宁占7.6%，黄酮类占6.2%，酚类占5.8%，生物碱占4.4%。5000mg/kg的剂量限值对大鼠使用是安全的。在100mg/kg的剂量下，该提取物减少了活性炭在胃肠道中的移动距离、蓖麻油诱导腹泻引起的排便频率和不成形粪便的数量，并导致腹泻效应的抑制率达到74.96%。 对较高浓度的提取物敏感，最低抑菌浓度为0.3125mg/mL。感染 的大鼠表现出抑郁、体重减轻、厌食、腹泻和虚弱，在治疗后第2天提取物使其症状得到改善。提取物改善了感染后观察到的肝脏、肠道和肾脏的充血、细胞浸润和坏死。
结论
提取物可用于治疗大鼠贫血以及蓖麻油和 诱导的腹泻。
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