Hoag Hospital, Newport Beach, California.
Keck School of Medicine, University of Southern California, Los Angeles, California.
Breast J. 2020 Jan;26(1):81-85. doi: 10.1111/tbj.13714. Epub 2020 Jan 14.
Pregnancy associated breast cancer (PABC) defined as breast cancer occurring during pregnancy or within the first 1-2 years postpartum. Delay in diagnosis is common. Treatment is timed around gestational age. Surgery and chemotherapy are considered safe after the first trimester. Radiation, anti-her-2, and endocrine therapy are delayed until after delivery due to adverse fetal effects. Iatrogenic prematurity likely causes most long-term fetal sequelae. Multi-disciplinary care and social support are critical for patients and families with PABC.
妊娠相关性乳腺癌(PABC)定义为妊娠期间或产后 1-2 年内发生的乳腺癌。诊断延迟较为常见。治疗时机取决于妊娠周数。孕早期后可安全进行手术和化疗。由于对胎儿有不良影响,放疗、抗 HER-2 和内分泌治疗需推迟至分娩后进行。医源性早产可能是导致大多数胎儿远期后遗症的主要原因。多学科护理和社会支持对 PABC 患者及其家庭至关重要。