Bukhman A I, Zarubina N A, Dorokhova I I, Kniazeva A P, Konnova E V
Probl Endokrinol (Mosk). 1988 Jul-Aug;34(4):7-12.
A study of patients with involution osteopathy has shown that the development of this disease is associated with osseous tissue dystrophic changes (osteoporosis) and, to a lesser extent, with osteomalacia. Involution osteopathy is not accompanied by severe changes in indices of phosphoric-calcium metabolism; it is characterized by a tendency to an increase in the levels of total and ionized calcium and a decrease in the level of serum phosphorus. A lowered level of calcitonin with a tendency to a decrease in the level of the somatotropic hormone and the unchanged content of parathormone was revealed in involution osteopathy. The blood level of sex steroids (both estradiol and testosterone) in women was decreased, a degree of a rise of gonadotropins in them was lower than that in healthy postmenopausal women. In men with involution osteopathy the mean level of serum testosterone was within low normal limits, the LH content remained normal, and a FSH level was raised. The level of prolactin in patients of both sexes was unchanged.
一项关于更年期骨质病患者的研究表明，这种疾病的发展与骨组织营养不良性变化（骨质疏松症）有关，在较小程度上还与骨软化症有关。更年期骨质病不会伴随磷钙代谢指标的严重变化；其特征是总钙和离子钙水平有升高趋势，而血清磷水平降低。研究发现，更年期骨质病患者体内降钙素水平降低，生长激素水平有下降趋势，甲状旁腺激素含量无变化。女性体内性类固醇（雌二醇和睾酮）的血液水平降低，其促性腺激素的升高程度低于健康绝经后女性。患有更年期骨质病的男性，其血清睾酮平均水平处于低正常范围，促黄体生成素含量正常，促卵泡激素水平升高。男女患者体内催乳素水平均无变化。
