Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
Department of Radiation Oncology, BC Cancer, University of British Columbia, Vancouver, BC, Canada.
Breast J. 2020 Jan;26(1):47-54. doi: 10.1111/tbj.13724. Epub 2020 Jan 15.
While there is now Level I data with long-term follow-up supporting the routine use of hypofractionated (HF) whole-breast radiation therapy (WBRT) after breast-conserving surgery, its adoption has been slow and variable. This article will review the literature supporting the efficacy and safety of hypofractionated radiation for breast cancer, discuss the radiobiological rationale specific to breast tumors, and make an argument for justifying the routine adoption of shorter, HF-WBRT courses when delivering breast radiation. Data using HF with regional nodal irradiation and in the post-mastectomy setting will also be reviewed. The aim is to provide an in-depth understanding of the use of hypofractionated radiation therapy for breast cancer, its applicability, and topics warranting future research.
目前已有一级数据并进行了长期随访，支持保乳手术后常规应用分割剂量（HF）全乳放射治疗（WBRT），但该方法的应用仍然缓慢且存在差异。本文将回顾支持乳腺癌分割剂量放射治疗有效性和安全性的文献，讨论针对乳腺肿瘤的放射生物学原理，并提出常规采用较短 HF-WBRT 疗程的理由。还将回顾区域淋巴结照射和乳房切除术后应用 HF 的相关数据。目的是深入了解乳腺癌分割剂量放射治疗的应用、适用性以及值得未来研究的课题。
