Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunts House, Guys Cam, London, SE1 1UL, UK.
Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunts House, Guys Cam, London, SE1 1UL, UK.
Curr Opin Cell Biol. 2020 Apr;63:31-37. doi: 10.1016/j.ceb.2019.12.008. Epub 2020 Jan 13.
Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix environment to the actin cytoskeleton via adaptor molecules through assembly of a range of adhesion structures. Recent advances in biochemical, imaging and biophysical methods have enabled a deeper understanding of integrin signalling and their associated regulatory processes. The identification of the consensus integrin-based 'adhesomes' within the last 5 years has defined common core components of adhesion complexes and associated partners. These approaches have also uncovered unexpected adhesion protein behaviour and molecules recruited to adhesion sites that have expanded our understanding of the molecular and physical control of integrin signalling.
整合素是异源二聚体跨膜受体，通过衔接分子将细胞外基质环境与肌动蛋白细胞骨架连接起来，通过组装一系列粘附结构。生化、成像和生物物理方法的最新进展使人们能够更深入地了解整合素信号及其相关调节过程。在过去的 5 年中，识别基于整合素的共识“黏着斑”定义了黏附复合物的常见核心成分和相关伙伴。这些方法还揭示了意想不到的黏附蛋白行为和募集到黏附位点的分子，从而扩展了我们对整合素信号的分子和物理控制的理解。
