一种用于诱发痛觉和自发痛觉感知的预测编码模型。
A Predictive Coding Model for Evoked and Spontaneous Pain Perception.
作者信息
Song Yuru, Kemprecos Helen, Wang Jing, Chen Zhe
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2964-2967. doi: 10.1109/EMBC.2019.8857298.
Abstract
Pain is a complex multidimensional experience, and pain perception is still incompletely understood. Here we combine animal behavior, electrophysiology, and computer modeling to dissect mechanisms of evoked and spontaneous pain. We record the local field potentials (LFPs) from the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC) of freely behaving rats during pain episodes, and develop a predictive coding model to investigate the temporal coordination of oscillatory activity between the S1 and ACC. Our preliminary results from computational simulations support the experimental findings and provide new predictions.
摘要
疼痛是一种复杂的多维度体验，而对疼痛感知的理解仍不完整。在此，我们结合动物行为、电生理学和计算机建模来剖析诱发痛和自发痛的机制。我们在疼痛发作期间记录自由活动大鼠的初级体感皮层（S1）和前扣带皮层（ACC）的局部场电位（LFP），并开发一种预测编码模型来研究S1和ACC之间振荡活动的时间协调性。我们计算模拟的初步结果支持了实验发现并提供了新的预测。
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本文引用的文献
1
Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex.
Front Cell Neurosci. 2019 Apr 24;13:165. doi: 10.3389/fncel.2019.00165. eCollection 2019.
2
Ensembles of change-point detectors: implications for real-time BMI applications.
J Comput Neurosci. 2019 Feb;46(1):107-124. doi: 10.1007/s10827-018-0694-8. Epub 2018 Sep 12.
3
Rate and Temporal Coding Mechanisms in the Anterior Cingulate Cortex for Pain Anticipation.
Sci Rep. 2018 May 29;8(1):8298. doi: 10.1038/s41598-018-26518-x.
4
Methodology for self-report of rest pain (or spontaneous pain) vs evoked pain in chronic neuropathic conditions: a prospective observational pilot study.
Pain Rep. 2017 Mar 10;2(2):e587. doi: 10.1097/PR9.0000000000000587. eCollection 2017 Mar.
5
Brain oscillations reflecting pain-related behavior in freely moving rats.
Pain. 2018 Jan;159(1):106-118. doi: 10.1097/j.pain.0000000000001069.
6
Chronic pain induces generalized enhancement of aversion.
Elife. 2017 May 19;6:e25302. doi: 10.7554/eLife.25302.
7
Brain Rhythms of Pain.
Trends Cogn Sci. 2017 Feb;21(2):100-110. doi: 10.1016/j.tics.2016.12.001. Epub 2016 Dec 23.
8
Deconstructing the sensation of pain: The influence of cognitive processes on pain perception.
Science. 2016 Nov 4;354(6312):584-587. doi: 10.1126/science.aaf8934.
9
Beta- and gamma-band activity reflect predictive coding in the processing of causal events.
Soc Cogn Affect Neurosci. 2016 Jun;11(6):973-80. doi: 10.1093/scan/nsw017. Epub 2016 Feb 12.
10
Alpha and gamma oscillation amplitudes synergistically predict the perception of forthcoming nociceptive stimuli.
Hum Brain Mapp. 2016 Feb;37(2):501-14. doi: 10.1002/hbm.23048. Epub 2015 Nov 2.
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