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缩宫素激惹试验的当前效用——一项单中心研究

The Present Utility of the Oxytocin Challenge Test-A Single-Center Study.

作者信息

Różańska-Walędziak Anna, Czajkowski Krzysztof, Walędziak Maciej, Teliga-Czajkowska Justyna

机构信息

2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, 00-315 Warsaw, Poland.

Department of General, Oncological, Metabolic and Thoracic Surgery, Military Institute of Medicine, 04-141 Warsaw, Poland.

出版信息

J Clin Med. 2020 Jan 3;9(1):131. doi: 10.3390/jcm9010131.

Abstract

INTRODUCTION

The oxytocin challenge test (OCT) used to be one of the most important tools in assessing fetal well-being before ultrasonography became prevalent. We show that, after modifying the classification of the results and the intervention algorithm, OCT can still be a useful tool in present-day obstetrics.

MATERIAL AND METHODS

The study included 318 OCTs performed in patients admitted to our department from 2010 to 2012. A modified classification of test results was introduced, dividing the results in four groups: I-negative, II-positive, III-non-diagnostic and type IV (fetal tachycardia or increased variability). The purpose of the study was to evaluate the clinical significance of OCT in assessing intrauterinal fetal well-being and predicting the necessity for ending the pregnancy.

RESULTS

A significant difference ( < 0.001) in the delivery method and the indications for cesarean sections (CS) was found between negative and positive OCT results. CS indicated by an abnormal fetal heart rate (FHR) pattern had to be performed in 40% of cases with positive OCT results, having constituted 84.6% of all CSs in this group. After negative OCTs, 12.8% pregnancies were ended by CS from FHR indications (62.3% of all the indications).

CONCLUSIONS

A positive OCT result can be a valuable predictor of an abnormal fetal heart rate pattern after the test and during the delivery, as well as a higher probability of a CS from cardiotocography (CTG) indications, with positive predictive value (PPV) 0.50 and negative predictive value (NPV) 0.85.

摘要

引言

在超声检查普及之前,催产素激惹试验(OCT)曾是评估胎儿健康状况的最重要工具之一。我们发现,在修改结果分类和干预算法后,OCT在当今产科中仍然是一种有用的工具。

材料与方法

本研究纳入了2010年至2012年在我科住院患者中进行的318例OCT。引入了一种修改后的试验结果分类,将结果分为四组:I组-阴性,II组-阳性,III组-非诊断性,IV组(胎儿心动过速或变异性增加)。本研究的目的是评估OCT在评估宫内胎儿健康状况和预测终止妊娠必要性方面的临床意义。

结果

阴性和阳性OCT结果在分娩方式和剖宫产(CS)指征方面存在显著差异(<0.001)。OCT结果为阳性的病例中,40%因胎儿心率(FHR)异常模式而需行CS,占该组所有CS的84.6%。OCT结果为阴性后(FHR指征),12.8%的妊娠通过CS终止(占所有指征的62.3%)。

结论

OCT结果为阳性可作为试验后及分娩期间胎儿心率异常模式的有价值预测指标,以及因胎心监护(CTG)指征行CS可能性较高的预测指标,其阳性预测值(PPV)为0.50,阴性预测值(NPV)为0.85。

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