Luo Chun-Wei, Zhao De-Hua, Liang Ge, Zhang Jie, Meng Yun, Jia Meng-Dan, Lu Jie
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Jan;22(1):37-41. doi: 10.7499/j.issn.1008-8830.2020.01.008.
To study the association of related maternal factors with the susceptibility to congenital hypothyroidism (CH) in neonates.
A case-control study was designed. The neonates who were diagnosed with CH in Neonatal Screening Center of Henan Province from January 1, 2016 to December 31, 2017 were enrolled as cases. Healthy neonates, matched for sex and age were enrolled as controls. A conditional logistic regression analysis and additive and multiplicative interaction analyses were used to identify the risk factors for susceptibility to CH.
A total of 2 771 661 neonates were screened during this period, among whom 1 494 neonates were diagnosed with CH, with a crude incidence rate of 53.9/100 000. A total of 843 pairs of the cases and the controls completed the telephone survey and provided qualified data. The conditional logistic regression analysis showed that an older maternal age at delivery, a low educational level in mothers, living in the rural area, a family history of thyroid diseases, histories of exposure to formaldehyde during pregnancy, exposure to radiation during pregnancy, and medication during pregnancy, were risk factors for CH (P<0.05), while low maternal age at delivery and progesterone intake during pregnancy were protective factors against CH (P<0.05).
An older maternal age at delivery, a low educational level in mothers, living in the rural area, a family history of thyroid diseases, and histories of exposure to formaldehyde during pregnancy, exposure to radiation during pregnancy and medication during pregnancy may increase the susceptibility to CH in neonates.
研究相关母体因素与新生儿先天性甲状腺功能减退症（CH）易感性的关联。
设计一项病例对照研究。将2016年1月1日至2017年12月31日在河南省新生儿筛查中心被诊断为CH的新生儿纳入病例组。选取年龄和性别相匹配的健康新生儿作为对照组。采用条件logistic回归分析以及相加和相乘交互作用分析来确定CH易感性的危险因素。
在此期间共筛查了2771661例新生儿，其中1494例被诊断为CH，粗发病率为53.9/10万。共有843对病例和对照完成了电话调查并提供了合格数据。条件logistic回归分析显示，产妇分娩时年龄较大、母亲文化程度低、居住在农村地区、有甲状腺疾病家族史、孕期有甲醛接触史、孕期有辐射接触史以及孕期用药，是CH的危险因素（P<0.05），而产妇分娩时年龄较小以及孕期服用孕酮是预防CH的保护因素（P<0.05）。
产妇分娩时年龄较大、母亲文化程度低、居住在农村地区、有甲状腺疾病家族史、孕期有甲醛接触史、孕期有辐射接触史以及孕期用药可能会增加新生儿患CH的易感性。
