Wilsher M L, Hughes D A, Haslam P L
Cell Biology Unit, Cardiothoracic Institute, London.
Thorax. 1988 May;43(5):354-9. doi: 10.1136/thx.43.5.354.
Human pulmonary surfactant has not been shown to have immunoregulatory properties. A study was designed to examine the effect of whole surfactant (lyophilised bronchoalveolar lavage fluid) and purified surfactant lipids obtained from normal lungs of three species (man, pig, rabbit) on the lymphoproliferative responses of human peripheral blood lymphocytes to mitogens and alloantigens. Whole surfactant and purified surfactant lipids suppressed the proliferative response to phytohaemagglutinin in a dose dependent manner. The purified lipid fraction appeared to cause more suppression than whole surfactant in all the species. There was significant suppression of the proliferative response to B cell mitogens, T cell mitogens (pokeweed mitogen and phytohaemagglutinin), and alloantigens as tested by allogeneic mixed lymphocyte cultures. These results suggest an immunoregulatory role for pulmonary surfactant, most likely due to the lipid fraction.
尚未证实人肺表面活性物质具有免疫调节特性。本研究旨在检测从三种物种（人、猪、兔）的正常肺中获取的全表面活性物质（冻干支气管肺泡灌洗液）和纯化的表面活性物质脂质对人外周血淋巴细胞对丝裂原和同种异体抗原的淋巴细胞增殖反应的影响。全表面活性物质和纯化的表面活性物质脂质以剂量依赖方式抑制对植物血凝素的增殖反应。在所有物种中，纯化的脂质部分似乎比全表面活性物质引起更多的抑制作用。通过同种异体混合淋巴细胞培养检测发现，对B细胞丝裂原、T细胞丝裂原（商陆丝裂原和植物血凝素）和同种异体抗原的增殖反应均有显著抑制。这些结果提示肺表面活性物质具有免疫调节作用，很可能是由于脂质部分所致。
