G-四链体的拓扑结构：配体的生物学功能和调控。

Topologies of G-quadruplex: Biological functions and regulation by ligands.

机构信息

Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Japan.

Department of Chemistry, Chiba University, Japan.

出版信息

Biochem Biophys Res Commun. 2020 Oct 8;531(1):3-17. doi: 10.1016/j.bbrc.2019.12.103. Epub 2020 Jan 14.

DOI:10.1016/j.bbrc.2019.12.103

PMID:31948752

Abstract

G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming sequences can generate three kinds of topologies, i.e., parallel, anti-parallel, and hybrid, and these polymorphic structures have an important influence on G4-related biological functions. In this review, we highlight variety of structures generated by G4s containing various sequences and under diverse conditions. We also discuss the G4 ligands which induce specific topologies and/or conversion between different topologies.

摘要

G-四链体 (G4) 是存在于富含鸟嘌呤的核酸序列中的一种高级结构，在生物过程中发挥着关键作用。形成 G4 的序列可以产生三种拓扑结构，即平行、反平行和混合，这些多态结构对 G4 相关的生物学功能有重要影响。在这篇综述中，我们强调了由含有各种序列和不同条件的 G4 产生的各种结构。我们还讨论了诱导特定拓扑结构和/或不同拓扑结构之间转换的 G4 配体。