文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

通过G-四链体的参与深入了解在血流形式和前循环形式中基因表达的表观遗传调控。

Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of through the involvement of G-quadruplexes.

作者信息

Belmonte-Reche Efres, Martínez-García Marta, de Jong Anne, Kuipers Oscar P, Cebrián Rubén

机构信息

Centre for Genomics and Oncological Research (GENYO), Avenida de la Ilustración 114, 18016, Granada , Spain.

Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain.

出版信息

NAR Genom Bioinform. 2025 Jul 17;7(3):lqaf100. doi: 10.1093/nargab/lqaf100. eCollection 2025 Sep.

DOI:10.1093/nargab/lqaf100
PMID:40677914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12267983/
Abstract

This study explores how G-quadruplexes (G4s) influence gene expression during the transition between bloodstream (BF) and procyclic (PC) forms of . Computational analysis identified over 115 000 G4-prone sequences, with 63% predicted to form stable G4 structures. These sequences are enriched in regions associated with antigenic variation, suggesting a role in gene regulation. Experimental validation using G4 ligands (AQ1, Pt-TTPY, and pyridostatin) showed a consistent downregulation of differentially expressed genes, supporting the potential relevance of targeting G4s. These results contribute to our understanding of epigenetic regulation in and may help inform future approaches for managing parasitic infections.

摘要

本研究探讨了G-四链体（G4s）在布氏锥虫血流（BF）型和前循环（PC）型转变过程中如何影响基因表达。通过计算分析确定了超过115000个易于形成G4的序列，其中63%预计会形成稳定的G4结构。这些序列在与抗原变异相关的区域富集，表明其在基因调控中发挥作用。使用G4配体（AQ1、Pt-TTPY和吡啶氨菌素）进行的实验验证显示，差异表达基因持续下调，支持了靶向G4s的潜在相关性。这些结果有助于我们理解布氏锥虫的表观遗传调控，并可能为未来管理寄生虫感染的方法提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/b95a5d52932b/lqaf100fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/880830d148b0/lqaf100fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/e8404f2e1a13/lqaf100fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/7114de6ba023/lqaf100fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/7c03249a58df/lqaf100fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/16f592fa336f/lqaf100fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/b95a5d52932b/lqaf100fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/880830d148b0/lqaf100fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/e8404f2e1a13/lqaf100fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/7114de6ba023/lqaf100fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/7c03249a58df/lqaf100fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/16f592fa336f/lqaf100fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3d/12267983/b95a5d52932b/lqaf100fig6.jpg

相似文献

[1]
Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of through the involvement of G-quadruplexes.

NAR Genom Bioinform. 2025-7-17

[2]
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells.

Genome Biol. 2025-7-12

[3]
Chemical and Genetic Validation of an Essential Calcium Entry Channel of as a Therapeutic Target.

ACS Infect Dis. 2025-6-13

[4]
In-depth analysis of the mode of action of resveratrol: genome-wide characterization of G-quadruplex binding properties.

Cell Mol Biol Lett. 2025-6-20

[5]
DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome.

Genome Biol. 2025-7-11

[6]
Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments.

Nucleic Acids Res. 2025-7-19

[7]
Stabilization of DNA G-quadruplexes on the 5'-flanking region of CYP3A4 promotes transcription.

Biochem Pharmacol. 2025-6-24

[8]
The Lived Experience of Autistic Adults in Employment: A Systematic Search and Synthesis.

Autism Adulthood. 2024-12-2

[9]
Controlling Topology of a Telomeric G-quadruplex DNA With a Chemical Cross-link.

Chemistry. 2025-6-18

[10]
G-quadruplexes are a source of vulnerability in deficient granule cell progenitors and medulloblastoma.

bioRxiv. 2024-7-22

本文引用的文献

[1]
Genome-wide chromatin interaction map for Trypanosoma cruzi.

Nat Microbiol. 2023-11

[2]
G-Quadruplexes as Key Transcriptional Regulators in Neglected Trypanosomatid Parasites.

Chembiochem. 2023-6-15

[3]
G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.

J Med Chem. 2022-3-24

[4]
G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands.

Nucleic Acids Res. 2022-1-7

[5]
G-quadruplex DNA: a novel target for drug design.

Cell Mol Life Sci. 2021-10

[6]
Unexpected plasticity in the life cycle of .

Elife. 2021-8-6

[7]
G-Quadruplex Structures in Bacteria: Biological Relevance and Potential as an Antimicrobial Target.

J Bacteriol. 2021-6-8

[8]
G-quadruplexes: a promising target for cancer therapy.

Mol Cancer. 2021-2-25

[9]
Where are G-quadruplexes located in the human transcriptome?

NAR Genom Bioinform. 2020-5-25

[10]
G4-iM Grinder: when size and frequency matter. G-Quadruplex, i-Motif and higher order structure search and analysis tool.

NAR Genom Bioinform. 2019-9-30

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索