鼻腔内翻性乳头状瘤进展为鳞状细胞癌过程中的拷贝数变异
Copy number variation in progression of inverted papilloma to squamous cell carcinoma of the nasal cavity.
作者信息
Shin Dong Hoon, Lee Jong-Kil, Cho Kyu-Sup, Roh Hwan-Jung
机构信息
Department of Pathology, Pusan National University Yangsan Hospital Yangsan, Republic of Korea.
Department of Otorhinolaryngology and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital Yangsan, Republic of Korea.
出版信息
Int J Clin Exp Pathol. 2018 Sep 1;11(9):4637-4643. eCollection 2018.
Inverted papilloma (IP) is a benign tumor occurring in nasal cavity. It can recur or progress to squamous cell carcinoma (SCC). The molecular mechanism of their biologic behavior is not fully revealed. Copy number variation (CNV) may contribute to progression of IP. We performed microarray comparative genome hybridization (aCGH). Five cases of IP, 2 cases of IP with dysplasia, 7 cases of SCC arising in a background of IP were submitted. The average numbers of somatic CNVs and copy number variable regions (CNVRs) were 991.9 and 866.9, respectively. Gain of 19p13.3, including 30 protein-coding genes, was observed in 2 IP and 7 SCC cases. Among those genes, BSG encoding the extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN)/CD147 may play more important role in the progression of IP to SCC. Further study for validation of the aCGH result is necessary.
内翻性乳头状瘤（IP）是一种发生于鼻腔的良性肿瘤。它可复发或进展为鳞状细胞癌（SCC）。其生物学行为的分子机制尚未完全阐明。拷贝数变异（CNV）可能与IP的进展有关。我们进行了微阵列比较基因组杂交（aCGH）。提交了5例IP、2例伴有发育异常的IP以及7例在IP背景下发生的SCC病例。体细胞CNV和拷贝数可变区域（CNVR）的平均数分别为991.9和866.9。在2例IP和7例SCC病例中观察到19p13.3区域的扩增，该区域包含30个蛋白质编码基因。在这些基因中，编码细胞外基质金属蛋白酶（MMP）诱导剂（EMMPRIN）/CD147的BSG可能在IP进展为SCC的过程中发挥更重要的作用。有必要进一步研究以验证aCGH结果。
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