酵母出芽生殖与 [SMAUG] 朊病毒：快不一定好。

Yeast Sporulation and [SMAUG] Prion: Faster Is Not Always Better.

机构信息

Institute of Biochemistry, Department of Biology, ETH, Zürich, Switzerland.

出版信息

Mol Cell. 2020 Jan 16;77(2):203-204. doi: 10.1016/j.molcel.2019.12.017.

DOI:10.1016/j.molcel.2019.12.017

PMID:31951543

Abstract

Chakravarty et al. (2019) and Itakura et al. (2019) report that the yeast RNA-binding protein Vts1 can convert into the [SMAUG] prion state and delay meiosis commitment in response to starvation. It enables budding yeast to optimize their sporulation efficiency depending on how quickly nutrient availability fluctuates in their environment.

摘要

查克拉瓦蒂等人（2019 年）和板仓等人（2019 年）报道称，酵母 RNA 结合蛋白 Vts1 可以转化为 [SMAUG] 朊病毒状态，并响应饥饿延迟减数分裂的启动。这使 budding yeast 能够根据其环境中营养物质可用性的变化速度优化其孢子形成效率。