Kühlkamp V, Ickrath O, Haasis R, Seipel L
Abteilung Innere Medizin III der Eberhard-Karls-Universität Tübingen.
Z Kardiol. 1988 Sep;77(9):595-9.
The effectiveness of Cibenzoline was assessed by means of programmed ventricular stimulation in 13 patients with sustained, drug refractory ventricular tachycardia. Besides Cibenzoline, an average of 3.5 antiarrhythmic drugs were tested, or were clinically ineffective. Cibenzoline was applied, i.v., in a dose of 1.5 mg/kg within 10 min. Cycle length was significantly shortened (p less than or equal to 0.05) while increases were noted for effective refractory period of the right ventricle (p less than or equal to 0.05), intranodal (AH-interval) and infranodal (HV-interval) conduction time (p less than or equal to 0.01), QRS-duration (p less than or equal to 0.001), QT-interval corrected for frequency (p less than or equal to 0.001) as well as cycle-length of the tachycardia (p less than or equal to 0.05). After i.v. Cibenzoline, induction of tachycardia was more difficult in two patients and unchanged in five patients. Spontaneous occurrence of the tachycardia was noted in three patients, and in one patient tachycardia was sustained by atrial stimulation. Cibenzoline i.v. prevented tachycardia in two patients respectively induction of tachycardia was not reproducible. It is concluded that Cibenzoline may be effective in individual patients with sustained ventricular tachycardia unresponsive to other antiarrhythmic drugs.
采用程控心室刺激法对13例持续性、药物难治性室性心动过速患者评估了西苯唑啉的有效性。除西苯唑啉外，平均还测试了3.5种抗心律失常药物，或这些药物临床无效。静脉注射西苯唑啉，剂量为1.5mg/kg，10分钟内注射完毕。心动周期明显缩短（p≤0.05），同时右心室有效不应期（p≤0.05）、结内（AH间期）和结下（HV间期）传导时间（p≤0.01）、QRS时限（p≤0.001）、经频率校正的QT间期（p≤0.001）以及心动过速的心动周期长度（p≤0.05）均增加。静脉注射西苯唑啉后，2例患者诱发心动过速更加困难，5例患者无变化。3例患者出现心动过速自发发作，1例患者心动过速由心房刺激维持。静脉注射西苯唑啉分别使2例患者的心动过速得到预防，或诱发心动过速不可重复。结论是，西苯唑啉可能对其他抗心律失常药物无效的持续性室性心动过速个体患者有效。
