Franken T h, Frommhold H, Thurn P
Strahlentherapie. 1977 Jan;153(1):40-5.
Out of a total number of 123 patients with non-Hodgkin lymphomas the result of local radiation therapy from 65 patients with lymphosarcomas or reticulosarcomas stage I or II are reported. In stage I, the tumor still being localized, there are good chances for recovery (3 or 4 years of survival without recurrenced in 75%). Already in stage II the percentages of a three-year survival without recurrences are reduced to 40% with lymphosarcomas and to 19% with recitulosarcomas. This most probably is due to an early, occult, already advanced cancerous spread, not having been recognized. More aggressive diagnostic measures for the staging, therefore, are recommandable. There are significant differences between lymphosarcomas and recitulosarcomas concerning their mode of propagation. Lymphosarcomas prefer the propagation into contiguous lymph node stations. With reticulosarcomas the generalisation to stage IV predominates at the first recurrence. For an improvement of the therapeutic results an irradiation is recommended which encompasses the adjacent lymphatics not yet being involved, the so-called "extended field technic". Early cytostatic therapy in stage II additionally has to be discussed, particularly for reticulosarcomas.
在123例非霍奇金淋巴瘤患者中，报告了65例I期或II期淋巴肉瘤或网状细胞肉瘤患者的局部放射治疗结果。在I期，肿瘤仍局限，恢复机会良好（75%的患者无复发存活3至4年）。在II期，淋巴肉瘤无复发三年生存率降至40%，网状细胞肉瘤则降至19%。这很可能是由于早期隐匿的、已经进展的癌性扩散未被识别。因此，建议采取更积极的分期诊断措施。淋巴肉瘤和网状细胞肉瘤在传播方式上存在显著差异。淋巴肉瘤倾向于向相邻淋巴结站扩散。网状细胞肉瘤首次复发时，IV期扩散占主导。为提高治疗效果，建议进行包括尚未受累的相邻淋巴管的照射，即所谓的“扩大野技术”。II期早期细胞抑制治疗也值得探讨，特别是对于网状细胞肉瘤。
